Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen Van den Bossche, Wafa' T Al-Jamal, Bowen Tian, Antonio Nunes, Chiara Fabbro, Alberto Bianco, Maurizio Prato, Kostas Kostarelos

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.
Original languageEnglish
Pages (from-to)7379-7381
Number of pages3
JournalChemical communications (Cambridge, England)
Volume46
Issue number39
DOIs
Publication statusPublished - 21 Oct 2010

Keywords

  • Microscopy, Electron, Transmission
  • Base Sequence
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • DNA Primers
  • Aptamers, Nucleotide
  • Biological Transport
  • Cell Line, Tumor
  • Receptors, Cell Surface
  • Nanotubes, Carbon

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