Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen Van den Bossche; Wafa' T Al-Jamal; Bowen Tian; Antonio Nunes; Chiara Fabbro; Alberto Bianco; Maurizio Prato; Kostas Kostarelos

doi:10.1039/c0cc02092c

Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Jeroen Van den Bossche
, Wafa' T Al-Jamal
, Bowen Tian
, Antonio Nunes
, Chiara Fabbro
, Alberto Bianco
, Maurizio Prato
, Kostas Kostarelos

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.

Original language	English
Pages (from-to)	7379-7381
Number of pages	3
Journal	Chemical communications (Cambridge, England)
Volume	46
Issue number	39
DOIs	https://doi.org/10.1039/c0cc02092c
Publication status	Published - 21 Oct 2010

Keywords

Microscopy, Electron, Transmission
Base Sequence
Electrophoresis, Polyacrylamide Gel
Humans
DNA Primers
Aptamers, Nucleotide
Biological Transport
Cell Line, Tumor
Receptors, Cell Surface
Nanotubes, Carbon

Access to Document

10.1039/c0cc02092c

Cite this

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abstract = "We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.",

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AU - Van den Bossche, Jeroen

AU - Al-Jamal, Wafa' T

AU - Tian, Bowen

AU - Nunes, Antonio

AU - Fabbro, Chiara

AU - Bianco, Alberto

AU - Prato, Maurizio

AU - Kostarelos, Kostas

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KW - Microscopy, Electron, Transmission

KW - Base Sequence

KW - Electrophoresis, Polyacrylamide Gel

KW - Humans

KW - DNA Primers

KW - Aptamers, Nucleotide

KW - Biological Transport

KW - Cell Line, Tumor

KW - Receptors, Cell Surface

KW - Nanotubes, Carbon

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