Electrical and mechanical components of dyssynchrony in heart failure patients with normal QRS duration and left bundle-branch block: impact of left and biventricular pacing

Mark S Turner, Rob A Bleasdale, Dragos Vinereanu, Catherine E Mumford, Vince Paul, Alan G Fraser, Michael P Frenneaux

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Resynchronization pacing is an effective symptomatic treatment for heart failure patients with prolongation of the QRS duration (QRSd). Dyssynchronous contraction of the left ventricle is also observed with normal QRSd. We set out to determine how electrical activation of the left ventricular (LV) free wall differed between patients with left bundle-branch block (LBBB) and normal QRSd and if synchrony improved during pacing in patients with normal QRSd.
Original languageEnglish
Pages (from-to)2544-2549
Number of pages6
JournalCirculation
Volume109
Issue number21
DOIs
Publication statusPublished - 1 Jun 2004

Keywords

  • Aged
  • Biomechanical Phenomena
  • Bundle-Branch Block
  • Cardiac Pacing, Artificial
  • Echocardiography, Doppler
  • Electrocardiography
  • Electrophysiology
  • Female
  • Heart Conduction System
  • Heart Failure
  • Heart Ventricles
  • Humans
  • Male
  • Middle Aged
  • Models, Cardiovascular
  • Myocardial Contraction
  • Systole
  • Time Factors
  • Ventricular Function, Left
  • Ventricular Function, Right

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