Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women

L. M. Browning, S. A. Jebb, G. D. Mishra, J. H. Cooke, M. A. O'Connell, M. A. Crook, J. D. Krebs

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39 Citations (Scopus)


AIMS: C-reactive protein (CRP) is a predictor of many diseases including type II diabetes and cardiovascular disease. Fewer studies have similarly shown sialic acid ( SA) to be a predictor of obesity-related diseases, but importantly SA shows less intraindividual variability than CRP and acts as an integrated marker of the activity of a number of acute-phase proteins. This study examines the association between both CRP and SA with individual and combined features of the metabolic syndrome. SUBJECTS: In all, 257 women with a body mass index (BMI) ranging from 25.1 to 54.5 kg/m(2) ( geometric mean 33.1 +/- 5.8 kg/m(2)) and aged 19 - 71 y (mean 45.6 +/- 12.1 y) were studied. Subjects had no symptoms of intercurrent infection, known diabetes, treated dyslipidaemia, a chronic inflammatory condition, liver disease or malignancy. RESULTS: Linear regression demonstrates that both CRP and SA were positively associated with weight, BMI, insulin resistance, dyslipidaemia and hypertension. There was a highly significant ( P
Original languageEnglish
Pages (from-to)1004-1010
Number of pages7
JournalInternational Journal of Obesity
Issue number8
Publication statusPublished - 2004

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