Emerging Linezolid-Resistant Enterococcus faecalis and Enterococcus faecium Isolated from Two Austrian Patients in the Same Intensive Care Unit

A Johnson, L Tysall, M Stockdale, N Woodford, M Kaufmann, M Warner, DM Livermore, F Asboth, F Allerberger

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110 Citations (Scopus)

Abstract

Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-susceptible isolates from the same patient, but differed from them by the same G2576U ribosomal RNA mutation. This is the first clinical case report of emerging resistance to linezolid among Enterococcus faecalis and also the first report of resistance involving vancomycin-susceptible rather than vancomycin-resistant enterococci. The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect.
Original languageEnglish
Pages (from-to)751-754
Number of pages4
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Volume21
Issue number10
DOIs
Publication statusPublished - Oct 2002

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