Encapsulation of drug molecules into Calix[n]arene Nanobaskets. Role of Aminocalix[n]arenes in biopharmaceutical field

E.V. Ukhatskaya, S.V. Kurkov, S.E. Matthews, T. Loftsson

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Calix[n]arenes (CAs) are supramolecular compounds able to form guest-host inclusion complexes with metal ions, small organic molecules, and small moieties of larger molecules. Although the CA literature is extensive, relatively few publications deal with water-soluble CAs, especially those containing nitrogen-based functionality. These CAs possess antibacterial and antifungal activity. Because of their molecular structure, they are surface active and also able to form water-soluble drug complexes, giving additional potential as enabling pharmaceutical excipients. This article provides an overview of the published data regarding synthesis, physicochemical properties, and pharmaceutical application of water-soluble CAs with emphasis on those that contain nitrogen-based substituents in their structure, particularly aminoCAs. In particular, it describes state-of-the-art in complexation of water-soluble CAs with pharmaceutically relevant ions and organic molecules up to amino acids, DNA, and proteins.
Original languageEnglish
Pages (from-to)3485-3512
Number of pages28
JournalJournal of Pharmaceutical Sciences
Volume102
Issue number10
DOIs
Publication statusPublished - 1 Oct 2013

Keywords

  • antiinfectives
  • calixarene
  • complexation
  • excipients
  • inclusion compounds
  • interaction
  • nanoparticles
  • structure-activity relationship
  • surfactants

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