Abstract
Calix[n]arenes (CAs) are supramolecular compounds able to form guest-host inclusion complexes with metal ions, small organic molecules, and small moieties of larger molecules. Although the CA literature is extensive, relatively few publications deal with water-soluble CAs, especially those containing nitrogen-based functionality. These CAs possess antibacterial and antifungal activity. Because of their molecular structure, they are surface active and also able to form water-soluble drug complexes, giving additional potential as enabling pharmaceutical excipients. This article provides an overview of the published data regarding synthesis, physicochemical properties, and pharmaceutical application of water-soluble CAs with emphasis on those that contain nitrogen-based substituents in their structure, particularly aminoCAs. In particular, it describes state-of-the-art in complexation of water-soluble CAs with pharmaceutically relevant ions and organic molecules up to amino acids, DNA, and proteins.
Original language | English |
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Pages (from-to) | 3485-3512 |
Number of pages | 28 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 102 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2013 |
Keywords
- antiinfectives
- calixarene
- complexation
- excipients
- inclusion compounds
- interaction
- nanoparticles
- structure-activity relationship
- surfactants