Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Paula Jakszyn, Sheila Bingham, Guillem Pera, Antonio Agudo, Robert Luben, Ailsa Welch, Heiner Boeing, Giuseppe Del Giudice, Domenico Palli, Calogero Saieva, Vittorio Krogh, Carlotta Sacerdote, Rosario Tumino, Salvatore Panico, Göran Berglund, Henrik Simán, Göran Hallmans, María José Sanchez, Nerea Larrañaga, Aurelio BarricarteMaría Dolores Chirlaque, José R Quirós, Timothy J Key, Naomi Allen, Eiliv Lund, Fátima Carneiro, Jakob Linseisen, Gabriele Nagel, Kim Overvad, Anne Tjonneland, Anja Olsen, H Bas Bueno-de-Mesquita, Marga O Ocké, Petra Hm Peeters, Mattijs E Numans, Françoise Clavel-Chapelon, Antonia Trichopoulou, Claus Fenger, Roger Stenling, Pietro Ferrari, Mazda Jenab, Teresa Norat, Elio Riboli, Carlos A Gonzalez

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147 Citations (Scopus)


The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was
Original languageEnglish
Pages (from-to)1497-1501
Number of pages5
Issue number7
Publication statusPublished - Jul 2006


  • Adenocarcinoma
  • Animals
  • Ascorbic Acid
  • Case-Control Studies
  • Cattle
  • Diet
  • Dimethylnitrosamine
  • Europe
  • Female
  • Helicobacter Infections
  • Helicobacter pylori
  • Humans
  • Iron
  • Male
  • Meat
  • Middle Aged
  • Nitrosamines
  • Prospective Studies
  • Risk Factors
  • Stomach Neoplasms

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