Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Paula Jakszyn; Sheila Bingham; Guillem Pera; Antonio Agudo; Robert Luben; Ailsa Welch; Heiner Boeing; Giuseppe Del Giudice; Domenico Palli; Calogero Saieva; Vittorio Krogh; Carlotta Sacerdote; Rosario Tumino; Salvatore Panico; Göran Berglund; Henrik Simán; Göran Hallmans; María José Sanchez; Nerea Larrañaga; Aurelio Barricarte; María Dolores Chirlaque; José R Quirós; Timothy J Key; Naomi Allen; Eiliv Lund; Fátima Carneiro; Jakob Linseisen; Gabriele Nagel; Kim Overvad; Anne Tjonneland; Anja Olsen; H Bas Bueno-de-Mesquita; Marga O Ocké; Petra Hm Peeters; Mattijs E Numans; Françoise Clavel-Chapelon; Antonia Trichopoulou; Claus Fenger; Roger Stenling; Pietro Ferrari; Mazda Jenab; Teresa Norat; Elio Riboli; Carlos A Gonzalez

doi:10.1093/carcin/bgl019

Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Paula Jakszyn, Sheila Bingham, Guillem Pera, Antonio Agudo, Robert Luben, Ailsa Welch, Heiner Boeing, Giuseppe Del Giudice, Domenico Palli, Calogero Saieva, Vittorio Krogh, Carlotta Sacerdote, Rosario Tumino, Salvatore Panico, Göran Berglund, Henrik Simán, Göran Hallmans, María José Sanchez, Nerea Larrañaga, Aurelio BarricarteMaría Dolores Chirlaque, José R Quirós, Timothy J Key, Naomi Allen, Eiliv Lund, Fátima Carneiro, Jakob Linseisen, Gabriele Nagel, Kim Overvad, Anne Tjonneland, Anja Olsen, H Bas Bueno-de-Mesquita, Marga O Ocké, Petra Hm Peeters, Mattijs E Numans, Françoise Clavel-Chapelon, Antonia Trichopoulou, Claus Fenger, Roger Stenling, Pietro Ferrari, Mazda Jenab, Teresa Norat, Elio Riboli, Carlos A Gonzalez

Research output: Contribution to journal › Article › peer-review

150 Citations (Scopus)

Abstract

The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was

Original language	English
Pages (from-to)	1497-1501
Number of pages	5
Journal	Carcinogenesis
Volume	27
Issue number	7
DOIs	https://doi.org/10.1093/carcin/bgl019
Publication status	Published - Jul 2006

Keywords

Adenocarcinoma
Animals
Ascorbic Acid
Case-Control Studies
Cattle
Diet
Dimethylnitrosamine
Europe
Female
Helicobacter Infections
Helicobacter pylori
Humans
Iron
Male
Meat
Middle Aged
Nitrosamines
Prospective Studies
Risk Factors
Stomach Neoplasms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/carcin/bgl019

Cite this

Jakszyn, P., Bingham, S., Pera, G., Agudo, A., Luben, R., Welch, A., Boeing, H., Del Giudice, G., Palli, D., Saieva, C., Krogh, V., Sacerdote, C., Tumino, R., Panico, S., Berglund, G., Simán, H., Hallmans, G., Sanchez, M. J., Larrañaga, N., ... Gonzalez, C. A. (2006). Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study. Carcinogenesis, 27(7), 1497-1501. https://doi.org/10.1093/carcin/bgl019

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abstract = "The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was ",

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author = "Paula Jakszyn and Sheila Bingham and Guillem Pera and Antonio Agudo and Robert Luben and Ailsa Welch and Heiner Boeing and {Del Giudice}, Giuseppe and Domenico Palli and Calogero Saieva and Vittorio Krogh and Carlotta Sacerdote and Rosario Tumino and Salvatore Panico and G{\"o}ran Berglund and Henrik Sim{\'a}n and G{\"o}ran Hallmans and Sanchez, {Mar{\'i}a Jos{\'e}} and Nerea Larra{\~n}aga and Aurelio Barricarte and Chirlaque, {Mar{\'i}a Dolores} and Quir{\'o}s, {Jos{\'e} R} and Key, {Timothy J} and Naomi Allen and Eiliv Lund and F{\'a}tima Carneiro and Jakob Linseisen and Gabriele Nagel and Kim Overvad and Anne Tjonneland and Anja Olsen and Bueno-de-Mesquita, {H Bas} and Ock{\'e}, {Marga O} and Peeters, {Petra Hm} and Numans, {Mattijs E} and Fran{\c c}oise Clavel-Chapelon and Antonia Trichopoulou and Claus Fenger and Roger Stenling and Pietro Ferrari and Mazda Jenab and Teresa Norat and Elio Riboli and Gonzalez, {Carlos A}",

year = "2006",

month = jul,

doi = "10.1093/carcin/bgl019",

language = "English",

volume = "27",

pages = "1497--1501",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

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Jakszyn, P, Bingham, S, Pera, G, Agudo, A, Luben, R, Welch, A, Boeing, H, Del Giudice, G, Palli, D, Saieva, C, Krogh, V, Sacerdote, C, Tumino, R, Panico, S, Berglund, G, Simán, H, Hallmans, G, Sanchez, MJ, Larrañaga, N, Barricarte, A, Chirlaque, MD, Quirós, JR, Key, TJ, Allen, N, Lund, E, Carneiro, F, Linseisen, J, Nagel, G, Overvad, K, Tjonneland, A, Olsen, A, Bueno-de-Mesquita, HB, Ocké, MO, Peeters, PH, Numans, ME, Clavel-Chapelon, F, Trichopoulou, A, Fenger, C, Stenling, R, Ferrari, P, Jenab, M, Norat, T, Riboli, E & Gonzalez, CA 2006, 'Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study', Carcinogenesis, vol. 27, no. 7, pp. 1497-1501. https://doi.org/10.1093/carcin/bgl019

TY - JOUR

T1 - Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

AU - Jakszyn, Paula

AU - Bingham, Sheila

AU - Pera, Guillem

AU - Agudo, Antonio

AU - Luben, Robert

AU - Welch, Ailsa

AU - Boeing, Heiner

AU - Del Giudice, Giuseppe

AU - Palli, Domenico

AU - Saieva, Calogero

AU - Krogh, Vittorio

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Berglund, Göran

AU - Simán, Henrik

AU - Hallmans, Göran

AU - Sanchez, María José

AU - Larrañaga, Nerea

AU - Barricarte, Aurelio

AU - Chirlaque, María Dolores

AU - Quirós, José R

AU - Key, Timothy J

AU - Allen, Naomi

AU - Lund, Eiliv

AU - Carneiro, Fátima

AU - Linseisen, Jakob

AU - Nagel, Gabriele

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Bueno-de-Mesquita, H Bas

AU - Ocké, Marga O

AU - Peeters, Petra Hm

AU - Numans, Mattijs E

AU - Clavel-Chapelon, Françoise

AU - Trichopoulou, Antonia

AU - Fenger, Claus

AU - Stenling, Roger

AU - Ferrari, Pietro

AU - Jenab, Mazda

AU - Norat, Teresa

AU - Riboli, Elio

AU - Gonzalez, Carlos A

PY - 2006/7

Y1 - 2006/7

N2 - The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was

AB - The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521,457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case-control within the cohort. Exposure to NDMA was

KW - Adenocarcinoma

KW - Animals

KW - Ascorbic Acid

KW - Case-Control Studies

KW - Cattle

KW - Diet

KW - Dimethylnitrosamine

KW - Europe

KW - Female

KW - Helicobacter Infections

KW - Helicobacter pylori

KW - Humans

KW - Iron

KW - Male

KW - Meat

KW - Middle Aged

KW - Nitrosamines

KW - Prospective Studies

KW - Risk Factors

KW - Stomach Neoplasms

U2 - 10.1093/carcin/bgl019

DO - 10.1093/carcin/bgl019

M3 - Article

C2 - 16571648

VL - 27

SP - 1497

EP - 1501

JO - Carcinogenesis

JF - Carcinogenesis

SN - 0143-3334

IS - 7

ER -