Enhanced NO signaling in patients with Takotsubo cardiomyopathy: short-term pain, long-term gain?

Thanh H Nguyen, Christopher J Neil, Aaron L Sverdlov, Doan T Ngo, Wai P Chan, Tamila Heresztyn, Yuliy Y Chirkov, Dimitrios Tsikas, Michael P Frenneaux, John D Horowitz

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36 Citations (Scopus)


Little information is available concerning the mechanism(s) underlying Takotsubo cardiomyopathy (TTC), other than evidence of associated catecholamine secretion. Given the known effects of catecholamines on endothelial function, we tested the hypothesis that TTC might also be associated with impairment of nitric oxide (NO) signaling. We now report an evaluation of NO signaling in TTC patients (vs. aged-matched controls) in relation to (a) severity of the acute attack and (b) rate of recovery.
Original languageEnglish
Pages (from-to)541-547
Number of pages7
JournalCardiovascular Drugs and Therapy
Issue number6
Publication statusPublished - 1 Dec 2013


  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nitric Oxide
  • Pain
  • Signal Transduction
  • Takotsubo Cardiomyopathy

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