Enhanced NO signaling in patients with Takotsubo cardiomyopathy: Short-term pain, long-term gain?

Thanh H Nguyen; Christopher J Neil; Aaron L Sverdlov; Doan T Ngo; Wai P Chan; Tamila Heresztyn; Yuliy Y Chirkov; Dimitrios Tsikas; Michael P Frenneaux; John D Horowitz

doi:10.1007/s10557-013-6481-x

Enhanced NO signaling in patients with Takotsubo cardiomyopathy: Short-term pain, long-term gain?

Thanh H Nguyen, Christopher J Neil, Aaron L Sverdlov, Doan T Ngo, Wai P Chan, Tamila Heresztyn, Yuliy Y Chirkov, Dimitrios Tsikas, Michael P Frenneaux, John D Horowitz

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Little information is available concerning the mechanism(s) underlying Takotsubo cardiomyopathy (TTC), other than evidence of associated catecholamine secretion. Given the known effects of catecholamines on endothelial function, we tested the hypothesis that TTC might also be associated with impairment of nitric oxide (NO) signaling. We now report an evaluation of NO signaling in TTC patients (vs. aged-matched controls) in relation to (a) severity of the acute attack and (b) rate of recovery.

Original language	English
Pages (from-to)	541-547
Number of pages	7
Journal	Cardiovascular Drugs and Therapy
Volume	27
Issue number	6
Early online date	7 Aug 2013
DOIs	https://doi.org/10.1007/s10557-013-6481-x
Publication status	Published - Dec 2013

Keywords

Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Nitric Oxide
Pain
Signal Transduction
Takotsubo Cardiomyopathy

Access to Document

10.1007/s10557-013-6481-x

Cite this

@article{cf58630608a24acfab10a7064923ecda,

title = "Enhanced NO signaling in patients with Takotsubo cardiomyopathy: Short-term pain, long-term gain?",

abstract = "Little information is available concerning the mechanism(s) underlying Takotsubo cardiomyopathy (TTC), other than evidence of associated catecholamine secretion. Given the known effects of catecholamines on endothelial function, we tested the hypothesis that TTC might also be associated with impairment of nitric oxide (NO) signaling. We now report an evaluation of NO signaling in TTC patients (vs. aged-matched controls) in relation to (a) severity of the acute attack and (b) rate of recovery.",

keywords = "Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Nitric Oxide, Pain, Signal Transduction, Takotsubo Cardiomyopathy",

author = "Nguyen, {Thanh H} and Neil, {Christopher J} and Sverdlov, {Aaron L} and Ngo, {Doan T} and Chan, {Wai P} and Tamila Heresztyn and Chirkov, {Yuliy Y} and Dimitrios Tsikas and Frenneaux, {Michael P} and Horowitz, {John D}",

year = "2013",

month = dec,

doi = "10.1007/s10557-013-6481-x",

language = "English",

volume = "27",

pages = "541--547",

journal = "Cardiovascular Drugs and Therapy",

issn = "0920-3206",