TY - JOUR
T1 - Enhancing central nervous system remyelination in multiple sclerosis
AU - Dubois-Dalcq, Monique
AU - ffrench-Constant, Charles
AU - Franklin, Robin J. M.
PY - 2005/10/6
Y1 - 2005/10/6
N2 - Recent studies on adult neural stem cells and the developmental biology of myelination have generated the expectation that neural precursors can repair the damaged central nervous system of multiple sclerosis patients where the endogenous remyelination process has failed. As a result, many laboratories are engaged in translational studies in which the goal is to design ways to promote remyelination and repair. Here we raise issues highlighted by prior experimental and human work that should be considered lest these studies become "lost in translation."
AB - Recent studies on adult neural stem cells and the developmental biology of myelination have generated the expectation that neural precursors can repair the damaged central nervous system of multiple sclerosis patients where the endogenous remyelination process has failed. As a result, many laboratories are engaged in translational studies in which the goal is to design ways to promote remyelination and repair. Here we raise issues highlighted by prior experimental and human work that should be considered lest these studies become "lost in translation."
UR - http://www.scopus.com/inward/record.url?scp=25644434410&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2005.09.004
DO - 10.1016/j.neuron.2005.09.004
M3 - Short survey
C2 - 16202704
AN - SCOPUS:25644434410
VL - 48
SP - 9
EP - 12
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -