Enhancing central nervous system remyelination in multiple sclerosis

Monique Dubois-Dalcq, Charles Ffrench-Constant, Robin J.M. Franklin

Research output: Contribution to journalShort surveypeer-review

103 Citations (Scopus)

Abstract

Recent studies on adult neural stem cells and the developmental biology of myelination have generated the expectation that neural precursors can repair the damaged central nervous system of multiple sclerosis patients where the endogenous remyelination process has failed. As a result, many laboratories are engaged in translational studies in which the goal is to design ways to promote remyelination and repair. Here we raise issues highlighted by prior experimental and human work that should be considered lest these studies become "lost in translation."

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalNeuron
Volume48
Issue number1
DOIs
Publication statusPublished - 6 Oct 2005

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