TY - JOUR
T1 - Enteroaggregative escherichia coli have evolved independently as distinct complexes within the E. Coli population with varying ability to cause disease
AU - Chattaway, Marie Anne
AU - Jenkins, Claire
AU - Rajendram, Dunstan
AU - Cravioto, Alejandro
AU - Talukder, Kaisar Ali
AU - Dallman, Tim
AU - Underwood, Anthony
AU - Platt, Steve
AU - Okeke, Iruka N.
AU - Wain, John
PY - 2014/11/21
Y1 - 2014/11/21
N2 - Enteroaggregative E. Coli (EAEC) is an established diarrhoeagenic pathotype. The association with virulence gene content and ability to cause disease has been studied but little is known about the population structure of EAEC and how this pathotype evolved. Analysis by Multi Locus Sequence Typing of 564 EAEC isolates from cases and controls in Bangladesh, Nigeria and the UK spanning the past 29 years, revealed multiple successful lineages of EAEC. The population structure of EAEC indicates some clusters are statistically associated with disease or carriage, further highlighting the heterogeneous nature of this group of organisms. Different clusters have evolved independently as a result of both mutational and recombination events; the EAEC phenotype is distributed throughout the population of E. coli.
AB - Enteroaggregative E. Coli (EAEC) is an established diarrhoeagenic pathotype. The association with virulence gene content and ability to cause disease has been studied but little is known about the population structure of EAEC and how this pathotype evolved. Analysis by Multi Locus Sequence Typing of 564 EAEC isolates from cases and controls in Bangladesh, Nigeria and the UK spanning the past 29 years, revealed multiple successful lineages of EAEC. The population structure of EAEC indicates some clusters are statistically associated with disease or carriage, further highlighting the heterogeneous nature of this group of organisms. Different clusters have evolved independently as a result of both mutational and recombination events; the EAEC phenotype is distributed throughout the population of E. coli.
UR - http://www.scopus.com/inward/record.url?scp=84913590704&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0112967
DO - 10.1371/journal.pone.0112967
M3 - Article
C2 - 25415318
AN - SCOPUS:84913590704
SN - 1932-6203
VL - 9
JO - PLoS One
JF - PLoS One
IS - 11
M1 - 0112967
ER -