Environmental factors in the relapse and recurrence of inflammatory bowel disease: A review of the literature

Thomas D. Martin; Simon S. M. Chan; Andrew R. Hart

doi:10.1007/s10620-014-3437-3

Environmental factors in the relapse and recurrence of inflammatory bowel disease: A review of the literature

Thomas D. Martin, Simon S. M. Chan, Andrew R. Hart

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

The causes of relapse in patients with Crohn's disease (CD) and ulcerative colitis (UC) are largely unknown. This paper reviews the epidemiological and clinical data on how medications (non-steroidal anti-inflammatory drugs, estrogens and antibiotics), lifestyle factors (smoking, psychological stress, diet and air pollution) may precipitate clinical relapses and recurrence. Potential biological mechanisms include: increasing thrombotic tendency, imbalances in prostaglandin synthesis, alterations in the composition of gut microbiota, and mucosal damage causing increased permeability.

Original language	English
Pages (from-to)	1396-1405
Number of pages	10
Journal	Digestive Diseases and Sciences
Volume	60
Issue number	5
Early online date	19 Nov 2014
DOIs	https://doi.org/10.1007/s10620-014-3437-3
Publication status	Published - May 2015

Keywords

Relapse
Recurrence
Inflammatory bowel disease
Precipitating factors

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10.1007/s10620-014-3437-3

Cite this

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abstract = "The causes of relapse in patients with Crohn's disease (CD) and ulcerative colitis (UC) are largely unknown. This paper reviews the epidemiological and clinical data on how medications (non-steroidal anti-inflammatory drugs, estrogens and antibiotics), lifestyle factors (smoking, psychological stress, diet and air pollution) may precipitate clinical relapses and recurrence. Potential biological mechanisms include: increasing thrombotic tendency, imbalances in prostaglandin synthesis, alterations in the composition of gut microbiota, and mucosal damage causing increased permeability.",

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