Epidemiology of asymptomatic pre-heart failure: A systematic review

Aurore Bergamasco, Anouk Luyet-Déruaz, Nicholas D. Gollop, Yola Moride, Qing Qiao

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
4 Downloads (Pure)


Purpose of Review: To quantify the prevalence of asymptomatic pre-heart failure (pre-HF), progression to more severe stages, and associated mortality. Recent Findings: A systematic review was conducted between 01 January 2010 and 12 March 2020 (PROSPERO: CRD42020176141). Data of interest included prevalence, disease progression, and mortality rates. In total, 1030 sources were identified, of which, 12 reported on pre-HF (using the ACC/AHA definition for stage B HF) and were eligible. Prevalence estimates of pre-HF ranged from 11 to 42.7% (10 sources) with higher estimates found in the elderly, in patients with hypertension, and in men. Three studies reported on disease progression with follow-up ranging from 13 months to 7 years. The incidence of symptomatic HF (HF/advanced HF) ranged from 0.63 to 9.8%, and all-cause mortality from 1.6 to 5.4%. Summary: Further research is required to investigate whether early detection and intervention can slow or stop the progression from asymptomatic to symptomatic HF.

Original languageEnglish
Article number203
Pages (from-to)146-156
Number of pages11
JournalCurrent Heart Failure Reports
Issue number3
Early online date30 Mar 2022
Publication statusPublished - Jun 2022
Externally publishedYes


  • Disease progression
  • Mortality
  • Prevalence
  • Stage B heart failure

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