Epidemiology of Cholesteatoma in the UK Biobank

Emma Wilson; Barbara Anne Jennings; Mizanur Khondoker; Carl M. Philpott; Peter Prinsley; Daniel S. Brewer

doi:10.1111/coa.14257

Epidemiology of Cholesteatoma in the UK Biobank

Emma Wilson, Barbara Anne Jennings, Mizanur Khondoker, Carl M. Philpott, Peter Prinsley, Daniel S. Brewer

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: To identify factors associated with cholesteatoma in a large UK cohort. Although some risk factors are frequently reported (male sex, history of chronic otitis media), other associations require further evidence (deprivation, smoking).

Design and Setting: Briefly, 1140 cholesteatoma cases from UK BioBank were compared to 4551 non-cholesteatoma middle ear disease and 493 832 ear disease-free controls. Adjusted odds ratios were calculated for demographic factors including age, sex, ethnicity, deprivation and smoking status with logistic regressions. Odds ratios for overlapping ICD-10 codes are also calculated.

Results: Cholesteatoma was significantly associated with sex (Adjusted odds ratio (AOR) for males = 1.33, 95%CI = [1.179–1.491]), age (AOR = 1.02, 95%CI = [1.011–1.026]) and deprivation (AOR = 1.08, 95%CI = [1.059–1.097]) compared to ear disease-free controls (p
Conclusion: This study shows a large overlap between cholesteatoma and non-cholesteatoma ear disease in terms of numbers and demographics, with sex being a key factor distinguishing between the two, suggesting that there are both common and distinct associated factors.

Original language	English
Journal	Clinical Otolaryngology
Early online date	4 Dec 2024
DOIs	https://doi.org/10.1111/coa.14257
Publication status	E-pub ahead of print - 4 Dec 2024

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10.1111/coa.14257Licence: CC BY

Epidemiology_of_Cholesteatoma_UKBB_main_manuscript_FINALAccepted author manuscript, 347 KBLicence: CC BY

Cite this

@article{d1dd72cb49df4e04aeb6813aa66bb12b,

title = "Epidemiology of Cholesteatoma in the UK Biobank",

abstract = "Objectives: To identify factors associated with cholesteatoma in a large UK cohort. Although some risk factors are frequently reported (male sex, history of chronic otitis media), other associations require further evidence (deprivation, smoking). Design and Setting: Briefly, 1140 cholesteatoma cases from UK BioBank were compared to 4551 non-cholesteatoma middle ear disease and 493 832 ear disease-free controls. Adjusted odds ratios were calculated for demographic factors including age, sex, ethnicity, deprivation and smoking status with logistic regressions. Odds ratios for overlapping ICD-10 codes are also calculated. Results: Cholesteatoma was significantly associated with sex (Adjusted odds ratio (AOR) for males = 1.33, 95%CI = [1.179–1.491]), age (AOR = 1.02, 95%CI = [1.011–1.026]) and deprivation (AOR = 1.08, 95%CI = [1.059–1.097]) compared to ear disease-free controls (p Conclusion: This study shows a large overlap between cholesteatoma and non-cholesteatoma ear disease in terms of numbers and demographics, with sex being a key factor distinguishing between the two, suggesting that there are both common and distinct associated factors.",

author = "Emma Wilson and Jennings, {Barbara Anne} and Mizanur Khondoker and Philpott, {Carl M.} and Peter Prinsley and Brewer, {Daniel S.}",

note = "Data Availability Statement: The data that support the findings of this study are available in UK BioBank after registering for access: (https://www.ukbiobank.ac.uk/enable-your-research/register). Publicly available demographic data and statistical results from FinnGen release 9 can be accessed via Risteys (https://r9.risteys.finngen.fi/endpoints/H8_CHOLEASTOMA). Funding: Funding for the studentship associated with this project was provided by the University of East Anglia Faculty of Medicine and Health Sciences. Funding for the greater Genetics of Cholesteatoma project was provided by the Bernice Bibby Research trust. Peer Review history: The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/coa.14257.",

year = "2024",

month = dec,

day = "4",

doi = "10.1111/coa.14257",

language = "English",

journal = "Clinical Otolaryngology",

issn = "1749-4478",

publisher = "Wiley",

}

TY - JOUR

T1 - Epidemiology of Cholesteatoma in the UK Biobank

AU - Wilson, Emma

AU - Jennings, Barbara Anne

AU - Khondoker, Mizanur

AU - Philpott, Carl M.

AU - Prinsley, Peter

AU - Brewer, Daniel S.

N1 - Data Availability Statement: The data that support the findings of this study are available in UK BioBank after registering for access: (https://www.ukbiobank.ac.uk/enable-your-research/register). Publicly available demographic data and statistical results from FinnGen release 9 can be accessed via Risteys (https://r9.risteys.finngen.fi/endpoints/H8_CHOLEASTOMA). Funding: Funding for the studentship associated with this project was provided by the University of East Anglia Faculty of Medicine and Health Sciences. Funding for the greater Genetics of Cholesteatoma project was provided by the Bernice Bibby Research trust. Peer Review history: The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/coa.14257.

PY - 2024/12/4

Y1 - 2024/12/4

N2 - Objectives: To identify factors associated with cholesteatoma in a large UK cohort. Although some risk factors are frequently reported (male sex, history of chronic otitis media), other associations require further evidence (deprivation, smoking). Design and Setting: Briefly, 1140 cholesteatoma cases from UK BioBank were compared to 4551 non-cholesteatoma middle ear disease and 493 832 ear disease-free controls. Adjusted odds ratios were calculated for demographic factors including age, sex, ethnicity, deprivation and smoking status with logistic regressions. Odds ratios for overlapping ICD-10 codes are also calculated. Results: Cholesteatoma was significantly associated with sex (Adjusted odds ratio (AOR) for males = 1.33, 95%CI = [1.179–1.491]), age (AOR = 1.02, 95%CI = [1.011–1.026]) and deprivation (AOR = 1.08, 95%CI = [1.059–1.097]) compared to ear disease-free controls (p Conclusion: This study shows a large overlap between cholesteatoma and non-cholesteatoma ear disease in terms of numbers and demographics, with sex being a key factor distinguishing between the two, suggesting that there are both common and distinct associated factors.

AB - Objectives: To identify factors associated with cholesteatoma in a large UK cohort. Although some risk factors are frequently reported (male sex, history of chronic otitis media), other associations require further evidence (deprivation, smoking). Design and Setting: Briefly, 1140 cholesteatoma cases from UK BioBank were compared to 4551 non-cholesteatoma middle ear disease and 493 832 ear disease-free controls. Adjusted odds ratios were calculated for demographic factors including age, sex, ethnicity, deprivation and smoking status with logistic regressions. Odds ratios for overlapping ICD-10 codes are also calculated. Results: Cholesteatoma was significantly associated with sex (Adjusted odds ratio (AOR) for males = 1.33, 95%CI = [1.179–1.491]), age (AOR = 1.02, 95%CI = [1.011–1.026]) and deprivation (AOR = 1.08, 95%CI = [1.059–1.097]) compared to ear disease-free controls (p Conclusion: This study shows a large overlap between cholesteatoma and non-cholesteatoma ear disease in terms of numbers and demographics, with sex being a key factor distinguishing between the two, suggesting that there are both common and distinct associated factors.

U2 - 10.1111/coa.14257

DO - 10.1111/coa.14257

M3 - Article

JO - Clinical Otolaryngology

JF - Clinical Otolaryngology

SN - 1749-4478

ER -