Epidemiology of ssymptomatic pre-heart failure: a systematic review

Aurore Bergamasco, Anouk Luyet-Déruaz, Nicholas D. Gollop, Yola Moride, Qing Qiao

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: To quantify the prevalence of asymptomatic pre-heart failure (pre-HF), progression to more severe stages, and associated mortality. Recent Findings: A systematic review was conducted between 01 January 2010 and 12 March 2020 (PROSPERO: CRD42020176141). Data of interest included prevalence, disease progression, and mortality rates. In total, 1030 sources were identified, of which, 12 reported on pre-HF (using the ACC/AHA definition for stage B HF) and were eligible. Prevalence estimates of pre-HF ranged from 11 to 42.7% (10 sources) with higher estimates found in the elderly, in patients with hypertension, and in men. Three studies reported on disease progression with follow-up ranging from 13 months to 7 years. The incidence of symptomatic HF (HF/advanced HF) ranged from 0.63 to 9.8%, and all-cause mortality from 1.6 to 5.4%. Summary: Further research is required to investigate whether early detection and intervention can slow or stop the progression from asymptomatic to symptomatic HF.

Original languageEnglish
Article number203
JournalCurrent Heart Failure Reports
Publication statusPublished - 30 Mar 2022
Externally publishedYes


  • Disease progression
  • Mortality
  • Prevalence
  • Stage B heart failure

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