Epoxide formation in the Friedel-Crafts reaction of adipoyl chloride and bromobenzene

Andrew N. Cammidge; Richard D. Kelsey; Amy S. H. King

doi:10.1016/S0040-4039(98)80043-9

Epoxide formation in the Friedel-Crafts reaction of adipoyl chloride and bromobenzene

Andrew N. Cammidge
, Richard D. Kelsey
, Amy S. H. King

Synthetic and Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The aluminium chloride catalysed Friedel-Crafts reaction between adipoyl chloride and bromobenzene has been re-examined. At elevated temperatures a number of side products are produced including a cyclopentane epoxide. The structure of this epoxide was elucidated by nmr and ir spectroscopy and its stereochemistry confirmed by x-ray crystallography.

Original language	English
Pages (from-to)	147-148
Number of pages	2
Journal	Tetrahedron Letters
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/S0040-4039(98)80043-9
Publication status	Published - 1 Jan 1999

Access to Document

10.1016/S0040-4039(98)80043-9

Cite this

@article{41e5cccf18694ddf8faea2e2c4b7c4a7,

title = "Epoxide formation in the Friedel-Crafts reaction of adipoyl chloride and bromobenzene",

abstract = "The aluminium chloride catalysed Friedel-Crafts reaction between adipoyl chloride and bromobenzene has been re-examined. At elevated temperatures a number of side products are produced including a cyclopentane epoxide. The structure of this epoxide was elucidated by nmr and ir spectroscopy and its stereochemistry confirmed by x-ray crystallography.",

author = "Cammidge, \{Andrew N.\} and Kelsey, \{Richard D.\} and King, \{Amy S. H.\}",

year = "1999",

month = jan,

day = "1",

doi = "10.1016/S0040-4039(98)80043-9",

language = "English",

volume = "40",

pages = "147--148",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Epoxide formation in the Friedel-Crafts reaction of adipoyl chloride and bromobenzene

AU - Cammidge, Andrew N.

AU - Kelsey, Richard D.

AU - King, Amy S. H.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The aluminium chloride catalysed Friedel-Crafts reaction between adipoyl chloride and bromobenzene has been re-examined. At elevated temperatures a number of side products are produced including a cyclopentane epoxide. The structure of this epoxide was elucidated by nmr and ir spectroscopy and its stereochemistry confirmed by x-ray crystallography.

AB - The aluminium chloride catalysed Friedel-Crafts reaction between adipoyl chloride and bromobenzene has been re-examined. At elevated temperatures a number of side products are produced including a cyclopentane epoxide. The structure of this epoxide was elucidated by nmr and ir spectroscopy and its stereochemistry confirmed by x-ray crystallography.

U2 - 10.1016/S0040-4039(98)80043-9

DO - 10.1016/S0040-4039(98)80043-9

M3 - Article

SN - 0040-4039

VL - 40

SP - 147

EP - 148

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 1

ER -