Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease

C M Lewis; S C L Whitwell; A Forbes; J Sanderson; C G Mathew; T M Marteau

doi:10.1136/jmg.2007.051672

Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease

C M Lewis, S C L Whitwell, A Forbes, J Sanderson, C G Mathew, T M Marteau

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Progress has been made in identifying mutations that confer susceptibility to complex diseases, with the prospect that these genetic risks might be used in determining individual disease risk.

Original language	English
Pages (from-to)	689-694
Number of pages	6
Journal	Journal of Medical Genetics
Volume	44
Issue number	11
DOIs	https://doi.org/10.1136/jmg.2007.051672
Publication status	Published - Nov 2007

Keywords

Adolescent
Adult
Bayes Theorem
Colitis, Ulcerative
Crohn Disease
Environmental Exposure
Europe
Family Health
Female
Gene Dosage
Genetic Heterogeneity
Genetic Predisposition to Disease
Humans
Male
Models, Genetic
Nod2 Signaling Adaptor Protein
Parents
Risk
Siblings
Smoking

Access to Document

10.1136/jmg.2007.051672

Cite this

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title = "Estimating risks of common complex diseases across genetic and environmental factors: the example of Crohn disease",

abstract = "Progress has been made in identifying mutations that confer susceptibility to complex diseases, with the prospect that these genetic risks might be used in determining individual disease risk.",

keywords = "Adolescent, Adult, Bayes Theorem, Colitis, Ulcerative, Crohn Disease, Environmental Exposure, Europe, Family Health, Female, Gene Dosage, Genetic Heterogeneity, Genetic Predisposition to Disease, Humans, Male, Models, Genetic, Nod2 Signaling Adaptor Protein, Parents, Risk, Siblings, Smoking",

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AU - Sanderson, J

AU - Mathew, C G

AU - Marteau, T M

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KW - Environmental Exposure

KW - Europe

KW - Family Health

KW - Female

KW - Gene Dosage

KW - Genetic Heterogeneity

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Models, Genetic

KW - Nod2 Signaling Adaptor Protein

KW - Parents

KW - Risk

KW - Siblings

KW - Smoking

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DO - 10.1136/jmg.2007.051672

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