Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity

Rachel M. Colquhoun, Ana da Silva Filipe, James Shepherd, David J. Pascall, Rajiv Shah, Natasha Jesudason, Kathy Li, Ruth Jarrett, Nicole Pacchiarini, Matthew Bull, Lily Geidelberg, Igor Siveroni, COG-UK Consortium, Ian Goodfellow, Nicholas J. Loman, Oliver G. Pybus, David L. Robertson, Emma C. Thomson, Andrew Rambaut, Thomas R. Connor

Research output: Contribution to journalArticlepeer-review

382 Citations (Scopus)

Abstract

Analysis of the spread and frequency of SARS-CoV-2 D614G in the United Kingdom suggests a selective advantage for this strain that is associated with higher viral loads in younger patients but not higher COVID-19 clinical severity or mortality.

Original languageEnglish
Pages (from-to)64-75.e11
JournalCell
Volume184
Issue number1
Early online date18 Nov 2020
DOIs
Publication statusPublished - 7 Jan 2021

Keywords

  • COVID-19
  • epidemiology
  • evolution
  • founder effect
  • SARS-CoV-2
  • spike

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