Evaluation of CD10 positivity in colorectal polyps in neoplastic transformation

Paolo Del Rio; Pellegrino Crafa; Cinzia Papadia; Paolo Dell'Abate; Angelo Franzè; Giacomo Franzini; Nicoletta Campanini; Mario Sianesi

Evaluation of CD10 positivity in colorectal polyps in neoplastic transformation

Paolo Del Rio, Pellegrino Crafa, Cinzia Papadia, Paolo Dell'Abate, Angelo Franzè, Giacomo Franzini, Nicoletta Campanini, Mario Sianesi

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

BACKGROUND: CD10 is a metalloprotein that is potentially associated with greater tumour growth.

MATERIALS AND METHOD: We have correlated CD10 positive in carcinomatous polyps with tumour size, grade, patient age and sex, postoperative TNM staging and Asler-Coller classification. We have matched these cases with a control group that showed presence of polypoid adenomatous tissue with mild to moderate dysplasia.

RESULTS: We have divided these in a group of 39 cases, characterised by the presence of carcinoma arising in adenomatous polyps, and a control group of 16 cases, characterised by the presence of colorectal polyps with mild to moderate dysplasia. In the first group, we have discarded three cases for incomplete data. In the remaining 36 cases we have identified 28 patients testing positive for CD10 with positivity values and 8 cases negative for CD10. In CD10 positive cases, we have confirmed the presence of increased incidence of lymph node involvement compared to CD10 negative cases, with high specificity and high predictive value and a higher incidence of cases attributable to group C (Asler-Coller) and grading 3.

CONCLUSIONS: CD10 positivity should be assessed in terms of increased progression.

Original language	English
Pages (from-to)	121-128
Number of pages	8
Journal	Annali Italiani di Chirurgia
Volume	81
Issue number	2
Publication status	Published - Mar 2010

Keywords

Aged
Case-Control Studies
Cell Transformation, Neoplastic
Colonic Polyps
Colorectal Neoplasms
Female
Humans
Intestinal Polyps
Male
Neprilysin
Rectal Neoplasms
Retrospective Studies

Cite this

@article{e7999f9324f9439fbd12a6fd127635a3,

title = "Evaluation of CD10 positivity in colorectal polyps in neoplastic transformation",

abstract = "BACKGROUND: CD10 is a metalloprotein that is potentially associated with greater tumour growth. MATERIALS AND METHOD: We have correlated CD10 positive in carcinomatous polyps with tumour size, grade, patient age and sex, postoperative TNM staging and Asler-Coller classification. We have matched these cases with a control group that showed presence of polypoid adenomatous tissue with mild to moderate dysplasia. RESULTS: We have divided these in a group of 39 cases, characterised by the presence of carcinoma arising in adenomatous polyps, and a control group of 16 cases, characterised by the presence of colorectal polyps with mild to moderate dysplasia. In the first group, we have discarded three cases for incomplete data. In the remaining 36 cases we have identified 28 patients testing positive for CD10 with positivity values and 8 cases negative for CD10. In CD10 positive cases, we have confirmed the presence of increased incidence of lymph node involvement compared to CD10 negative cases, with high specificity and high predictive value and a higher incidence of cases attributable to group C (Asler-Coller) and grading 3. CONCLUSIONS: CD10 positivity should be assessed in terms of increased progression. ",

keywords = "Aged, Case-Control Studies, Cell Transformation, Neoplastic, Colonic Polyps, Colorectal Neoplasms, Female, Humans, Intestinal Polyps, Male, Neprilysin, Rectal Neoplasms, Retrospective Studies",

author = "{Del Rio}, Paolo and Pellegrino Crafa and Cinzia Papadia and Paolo Dell'Abate and Angelo Franz{\`e} and Giacomo Franzini and Nicoletta Campanini and Mario Sianesi",

year = "2010",

month = mar,

language = "English",

volume = "81",

pages = "121--128",

journal = "Annali Italiani di Chirurgia",

issn = "0003-469X",

publisher = "Edizioni Luigi Pozzi S.r.l.",

number = "2",

}

TY - JOUR

T1 - Evaluation of CD10 positivity in colorectal polyps in neoplastic transformation

AU - Del Rio, Paolo

AU - Crafa, Pellegrino

AU - Papadia, Cinzia

AU - Dell'Abate, Paolo

AU - Franzè, Angelo

AU - Franzini, Giacomo

AU - Campanini, Nicoletta

AU - Sianesi, Mario

PY - 2010/3

Y1 - 2010/3

N2 - BACKGROUND: CD10 is a metalloprotein that is potentially associated with greater tumour growth. MATERIALS AND METHOD: We have correlated CD10 positive in carcinomatous polyps with tumour size, grade, patient age and sex, postoperative TNM staging and Asler-Coller classification. We have matched these cases with a control group that showed presence of polypoid adenomatous tissue with mild to moderate dysplasia. RESULTS: We have divided these in a group of 39 cases, characterised by the presence of carcinoma arising in adenomatous polyps, and a control group of 16 cases, characterised by the presence of colorectal polyps with mild to moderate dysplasia. In the first group, we have discarded three cases for incomplete data. In the remaining 36 cases we have identified 28 patients testing positive for CD10 with positivity values and 8 cases negative for CD10. In CD10 positive cases, we have confirmed the presence of increased incidence of lymph node involvement compared to CD10 negative cases, with high specificity and high predictive value and a higher incidence of cases attributable to group C (Asler-Coller) and grading 3. CONCLUSIONS: CD10 positivity should be assessed in terms of increased progression.

AB - BACKGROUND: CD10 is a metalloprotein that is potentially associated with greater tumour growth. MATERIALS AND METHOD: We have correlated CD10 positive in carcinomatous polyps with tumour size, grade, patient age and sex, postoperative TNM staging and Asler-Coller classification. We have matched these cases with a control group that showed presence of polypoid adenomatous tissue with mild to moderate dysplasia. RESULTS: We have divided these in a group of 39 cases, characterised by the presence of carcinoma arising in adenomatous polyps, and a control group of 16 cases, characterised by the presence of colorectal polyps with mild to moderate dysplasia. In the first group, we have discarded three cases for incomplete data. In the remaining 36 cases we have identified 28 patients testing positive for CD10 with positivity values and 8 cases negative for CD10. In CD10 positive cases, we have confirmed the presence of increased incidence of lymph node involvement compared to CD10 negative cases, with high specificity and high predictive value and a higher incidence of cases attributable to group C (Asler-Coller) and grading 3. CONCLUSIONS: CD10 positivity should be assessed in terms of increased progression.

KW - Aged

KW - Case-Control Studies

KW - Cell Transformation, Neoplastic

KW - Colonic Polyps

KW - Colorectal Neoplasms

KW - Female

KW - Humans

KW - Intestinal Polyps

KW - Male

KW - Neprilysin

KW - Rectal Neoplasms

KW - Retrospective Studies

M3 - Article

C2 - 20726390

VL - 81

SP - 121

EP - 128

JO - Annali Italiani di Chirurgia

JF - Annali Italiani di Chirurgia

SN - 0003-469X

IS - 2

ER -