Evaluation of chamomile oil and nanoemulgels as a promising treatment option for atopic dermatitis induced in rats

Noha S. El-Salamouni, Mai M. Ali, Sherien A. Abdelhady, Lamia S. Kandil, Gihan A. Elbatouti, Ragwa M. Farid

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: Atopic dermatitis is a chronic inflammatory skin disease that remarkably affects the quality-of-life of patients. Chamomile oil is used to treat skin inflammations. We evaluated the efficacy of chamomile oil and nanoemulgel formulations as a natural alternative therapeutic option for atopic dermatitis.

Research design and methods: Formulations were developed comprising chamomile oil: olive oil (1:1), Tween 20/80 or Gelucire 44/14 as surfactant-cosurfactant mixtures, propylene glycol (10%w/w), water and hydroxypropyl methylcellulose (3%w/w). In-vitro physicochemical characterization, stability testing and in-vivo assessment of inflammatory biomarkers and histopathological examination of skin lesions were conducted in rats induced with atopic dermatitis.

Results: Nanoemulgels G1 and X1 which displayed the smallest particle size of 137.5 ± 2.04 and 207.1 ± 5.44 nm, good homogeneity and high zeta-potential values of –26.4 and –32.7 mV were selected as the optimized emulgel. Nanoemulgels were nonirritating of pH value 5.56, readily spreadable, and were physically stable following 10 heating-cooling cycles. Treatment with nanoemulgels showed a two-fold decrease in duration of skin healing and no spongiosis compared to chamomile oil. Levels of biomarkers were reduced after topical application of both nanoemulgels and chamomile oil.

Conclusion: Nanoemulgels are a potential cost effective, safe topical carrier system for chamomile in treating atopic dermatitis.
Original languageEnglish
Pages (from-to)111-122
Number of pages12
JournalExpert Opinion on Drug Delivery
Issue number1
Early online date6 Dec 2019
Publication statusPublished - 2020


  • Atopic dermatitis
  • chamomile oil
  • inflammatory biomarkers
  • nanoemulgel
  • olive oil

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