Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues

Ryan C. Clark, Sang Yeul Lee, Inkyu Hwang, Mark Searcey, Dale L. Boger

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8 Citations (Scopus)

Abstract

Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.
Original languageEnglish
Pages (from-to)3151-3153
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number26
DOIs
Publication statusPublished - 1 Jul 2009

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