Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues

Ryan C. Clark; Sang Yeul Lee; Inkyu Hwang; Mark Searcey; Dale L. Boger

doi:10.1016/j.tetlet.2009.01.081

Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues

Ryan C. Clark, Sang Yeul Lee, Inkyu Hwang, Mark Searcey, Dale L. Boger

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.

Original language	English
Pages (from-to)	3151-3153
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2009.01.081
Publication status	Published - 1 Jul 2009

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10.1016/j.tetlet.2009.01.081

Cite this

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title = "Evaluation of chlorofusin, its seven chromophore diastereomers, and key analogues",

abstract = "Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.",

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AU - Clark, Ryan C.

AU - Lee, Sang Yeul

AU - Hwang, Inkyu

AU - Searcey, Mark

AU - Boger, Dale L.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.

AB - Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2–p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.

U2 - 10.1016/j.tetlet.2009.01.081

DO - 10.1016/j.tetlet.2009.01.081

M3 - Article

VL - 50

SP - 3151

EP - 3153

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 26

ER -