@article{4c7984b19f19469a96a26b1eec07faf5,
title = "Evolution of genes and genomes on the Drosophila phylogeny",
abstract = "Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.",
author = "Clark, {Andrew G.} and Eisen, {Michael B.} and Smith, {Douglas R.} and Bergman, {Casey M.} and Brian Oliver and Markow, {Therese A.} and Kaufman, {Thomas C.} and Manolis Kellis and William Gelbart and Iyer, {Venky N.} and Pollard, {Daniel A.} and Sackton, {Timothy B.} and Larracuente, {Amanda M.} and Singh, {Nadia D.} and Abad, {Jose P.} and Abt, {Dawn N.} and Boris Adryan and Montserrat Aguade and Hiroshi Akashi and Anderson, {Wyatt W.} and Aquadro, {Charles F.} and Ardell, {David H.} and Roman Arguello and Artieri, {Carlo G.} and Barbash, {Daniel A.} and Daniel Barker and Paolo Barsanti and Phil Batterham and Serafim Batzoglou and Dave Begun and Arjun Bhutkar and Enrico Blanco and Bosak, {Stephanie A.} and Bradley, {Robert K.} and Brand, {Adrianne D.} and Brent, {Michael R.} and Brooks, {Angela N.} and Brown, {Randall H.} and Butlin, {Roger K.} and Corrado Caggese and Calvi, {Brian R.} and {de Carvalho}, {A. Bernardo} and Anat Caspi and Sergio Castrezana and Celniker, {Susan E.} and Chang, {Jean L.} and Charles Chapple and Sourav Chatterji and Anastasia Gardiner and Wilfried Haerty and {Drosophila 12 Genomes Consortium}",
note = "Acknowledgements Agencourt Bioscience Corporation, The Broad Institute of MIT and Harvard and the Washington University Genome Sequencing Center were supported by grants and contracts from the National Human Genome Research Insititute (NHGRI). T.C. Kaufman acknowledges support from the Indian Genomics Initiative.",
year = "2007",
month = nov,
day = "8",
doi = "10.1038/nature06341",
language = "English",
volume = "450",
pages = "203--218",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7167",
}