Evolution of Salmonella within hosts

Jennifer R. Tanner, Robert A. Kingsley

Research output: Contribution to journalReview articlepeer-review

64 Citations (Scopus)
19 Downloads (Pure)


Within-host evolution has resulted in thousands of variants of Salmonella that exhibit remarkable diversity in host range and disease outcome, from broad host range to exquisite host restriction, causing gastroenteritis to disseminated disease such as typhoid fever. Within-host evolution is a continuing process driven by genomic variation that occurs during each infection, potentiating adaptation to a new niche resulting from changes in animal husbandry, the use of antimicrobials, and emergence of immune compromised populations. We discuss key advances in our understanding of the evolution of Salmonella within the host, inferred from (i) the process of host adaptation of Salmonella pathovars in the past, and (ii) direct observation of the generation of variation and selection of beneficial traits during single infections.

Original languageEnglish
Pages (from-to)986-998
Number of pages13
JournalTrends in Microbiology
Issue number12
Early online date25 Jun 2018
Publication statusPublished - Dec 2018


  • adaptation
  • evolution
  • pathogenesis
  • Salmonella

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