Exercise capacity in hypertrophic cardiomyopathy. Role of stroke volume limitation, heart rate, and diastolic filling characteristics

Suhas S. Lele, Helen L. Thomson, Hiromi Seo, Israel Belenkie, William J. McKenna, Michael P. Frenneaux

Research output: Contribution to journalArticlepeer-review

160 Citations (Scopus)


We previously showed that exercise capacity in patients with hypertrophic cardiomyopathy (HCM) is related to peak exercise cardiac output. Cardiac output augmentation during exercise is normally dependent on heart rate (HR) response and stroke volume (SV) augmentation by increased left ventricular end-diastolic volume and/or increased contractility. We hypothesized that in contrast to normal subjects, peak exercise capacity in patients with HCM is determined by the diastolic filling characteristics of the left ventricle during exercise, which would in turn determine the degree to which SV is augmented, and that HR is a relatively unimportant determinant of peak exercise capacity.
Original languageEnglish
Pages (from-to)2886-94
Number of pages9
Issue number10
Publication statusPublished - 15 Nov 1995


  • Adult
  • Cardiomyopathy, Hypertrophic
  • Case-Control Studies
  • Exercise Test
  • Exercise Tolerance
  • Female
  • Gated Blood-Pool Imaging
  • Heart
  • Hemodynamics
  • Humans
  • Male
  • Oxygen Consumption
  • Sodium Pertechnetate Tc 99m
  • Stroke Volume
  • Ventricular Function, Left

Cite this