Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes

S.P. Bew, R.A. Brimage, D.L. Hughes, L. Legentil, S.V. Sharma, M.A. Wilson

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Abstract

An efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported. © 2007 American Chemical Society.
Original languageEnglish
Pages (from-to)2655-2658
Number of pages4
JournalThe Journal of Organic Chemistry
Volume72
Issue number7
DOIs
Publication statusPublished - 30 Mar 2007

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