Experimental approaches for gene regulatory network construction: The chick as a model system: Gene Regulatory Network Construction

Andrea Streit, Monica Tambalo, Jingchen Chen, Timothy Grocott, Maryam Anwar, Alona Sosinsky, Claudio D. Stern

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Setting up the body plan during embryonic development requires the coordinated action of many signals and transcriptional regulators in a precise temporal sequence and spatial pattern. The last decades have seen an explosion of information describing the molecular control of many developmental processes. The next challenge is to integrate this information into logic “wiring diagrams” that visualize gene actions and outputs, have predictive power and point to key control nodes. Here, we provide an experimental workflow on how to construct gene regulatory networks using the chick as model system.
Original languageEnglish
Pages (from-to)296-310
Number of pages14
Journalgenesis
Volume51
Issue number5
DOIs
Publication statusPublished - 1 May 2013

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