Experimental approaches for gene regulatory network construction: The chick as a model system

Andrea Streit, Monica Tambalo, Jingchen Chen, Timothy Grocott, Maryam Anwar, Alona Sosinsky, Claudio D. Stern

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Setting up the body plan during embryonic development requires the coordinated action of many signals and transcriptional regulators in a precise temporal sequence and spatial pattern. The last decades have seen an explosion of information describing the molecular control of many developmental processes. The next challenge is to integrate this information into logic “wiring diagrams” that visualize gene actions and outputs, have predictive power and point to key control nodes. Here, we provide an experimental workflow on how to construct gene regulatory networks using the chick as model system.
Original languageEnglish
Pages (from-to)296-310
Number of pages14
Issue number5
Early online date23 Nov 2012
Publication statusPublished - May 2013

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