Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

Tomislav Friščić; Laszlo Fabian; Jonathan C. Burley; William Jones; W. D. Samuel Motherwell

doi:10.1039/b613073a

Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

Tomislav Friščić, Laszlo Fabian, Jonathan C. Burley, William Jones, W. D. Samuel Motherwell

Pharmaceutical Materials and Soft Matter

Research output: Contribution to journal › Article › peer-review

104 Citations (Scopus)

Abstract

The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal–cocrystal reactions.

Original language	English
Pages (from-to)	5009-5011
Number of pages	3
Journal	Chemical Communications
Issue number	48
DOIs	https://doi.org/10.1039/b613073a
Publication status	Published - 9 Nov 2006

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10.1039/b613073a

Cite this

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title = "Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals",

abstract = "The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal–cocrystal reactions.",

author = "Tomislav Fri{\v s}{\v c}i{\'c} and Laszlo Fabian and Burley, {Jonathan C.} and William Jones and Motherwell, {W. D. Samuel}",

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T1 - Exploring cocrystal-cocrystal reactivity via liquid-assisted grinding: the assembling of racemic and dismantling of enantiomeric cocrystals

AU - Friščić, Tomislav

AU - Fabian, Laszlo

AU - Burley, Jonathan C.

AU - Jones, William

AU - Motherwell, W. D. Samuel

PY - 2006/11/9

Y1 - 2006/11/9

N2 - The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal–cocrystal reactions.

AB - The reaction between pairs of enantiomeric cocrystals involving caffeine or theophylline and a chiral cocrystal former has been investigated by liquid-assisted grinding: we demonstrate two different outcomes for such cocrystal–cocrystal reactions.

U2 - 10.1039/b613073a

DO - 10.1039/b613073a

M3 - Article

SP - 5009

EP - 5011

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 48

ER -