Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study

Yingchang Lu, Edith J M Feskens, Jolanda M A Boer, Sandra Imholz, W M Monique Verschuren, Cisca Wijmenga, Anika Vaarhorst, Eline Slagboom, Michael Müller, Martijn E T Dollé

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Plasma total cholesterol (TC) levels are highly genetically determined. Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has been reported, using TC level directly as a phenotype in a relatively large broad-gene based association study has not been reported to date.
Original languageEnglish
Pages (from-to)200-205
Number of pages6
Issue number1
Publication statusPublished - Nov 2010


  • Adult
  • Body Mass Index
  • Cholesterol
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Lipoproteins
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Predictive Value of Tests
  • Risk

Cite this