Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study

Yingchang Lu; Edith J M Feskens; Jolanda M A Boer; Sandra Imholz; W M Monique Verschuren; Cisca Wijmenga; Anika Vaarhorst; Eline Slagboom; Michael Müller; Martijn E T Dollé

doi:10.1016/j.atherosclerosis.2010.08.053

Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study

Yingchang Lu, Edith J M Feskens, Jolanda M A Boer, Sandra Imholz, W M Monique Verschuren, Cisca Wijmenga, Anika Vaarhorst, Eline Slagboom, Michael Müller, Martijn E T Dollé

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Plasma total cholesterol (TC) levels are highly genetically determined. Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has been reported, using TC level directly as a phenotype in a relatively large broad-gene based association study has not been reported to date.

Original language	English
Pages (from-to)	200-205
Number of pages	6
Journal	Atherosclerosis
Volume	213
Issue number	1
DOIs	https://doi.org/10.1016/j.atherosclerosis.2010.08.053
Publication status	Published - Nov 2010

Keywords

Adult
Body Mass Index
Cholesterol
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Lipoproteins
Longitudinal Studies
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Predictive Value of Tests
Risk

Access to Document

10.1016/j.atherosclerosis.2010.08.053

Cite this

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title = "Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study",

abstract = "Plasma total cholesterol (TC) levels are highly genetically determined. Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has been reported, using TC level directly as a phenotype in a relatively large broad-gene based association study has not been reported to date.",

keywords = "Adult, Body Mass Index, Cholesterol, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Lipoproteins, Longitudinal Studies, Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Predictive Value of Tests, Risk",

author = "Yingchang Lu and Feskens, {Edith J M} and Boer, {Jolanda M A} and Sandra Imholz and Verschuren, {W M Monique} and Cisca Wijmenga and Anika Vaarhorst and Eline Slagboom and Michael M{\"u}ller and Doll{\'e}, {Martijn E T}",

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language = "English",

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AU - Lu, Yingchang

AU - Feskens, Edith J M

AU - Boer, Jolanda M A

AU - Imholz, Sandra

AU - Verschuren, W M Monique

AU - Wijmenga, Cisca

AU - Vaarhorst, Anika

AU - Slagboom, Eline

AU - Müller, Michael

AU - Dollé, Martijn E T

PY - 2010/11

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N2 - Plasma total cholesterol (TC) levels are highly genetically determined. Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has been reported, using TC level directly as a phenotype in a relatively large broad-gene based association study has not been reported to date.

AB - Plasma total cholesterol (TC) levels are highly genetically determined. Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has been reported, using TC level directly as a phenotype in a relatively large broad-gene based association study has not been reported to date.

KW - Adult

KW - Body Mass Index

KW - Cholesterol

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Lipoproteins

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Predictive Value of Tests

KW - Risk

U2 - 10.1016/j.atherosclerosis.2010.08.053

DO - 10.1016/j.atherosclerosis.2010.08.053

M3 - Article

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SP - 200

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JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -