Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?

Tomislav Friščić, Laszlo Fabian, Jonathan C. Burley, David G. Reid, Melinda J. Duer, William Jones

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.
Original languageEnglish
Pages (from-to)1644-1646
Number of pages3
JournalChemical Communications
Issue number14
DOIs
Publication statusPublished - 30 Jan 2008

Cite this