Exploring the relationship between cocrystal stability and symmetry: is Wallach's rule applicable to multi-component solids?

Tomislav Friščić, Laszlo Fabian, Jonathan C. Burley, David G. Reid, Melinda J. Duer, William Jones

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


Comparison of structure and hydration stability of pairs of chiral and racemic binary cocrystals indicates that the racemic solid is more stable than the chiral one; we illustrate that this difference might arise from intermolecular (crystal packing) factors in one case, while intramolecular (molecular conformation) factors are more significant in the other.
Original languageEnglish
Pages (from-to)1644-1646
Number of pages3
JournalChemical Communications
Issue number14
Publication statusPublished - 30 Jan 2008

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