Expression of Bcl-2, p53, and MDM2 in localized prostate cancer with respect to the outcome of radical radiotherapy dose escalation

Roy Vergis; Catherine M Corbishley; Karen Thomas; Alan Horwich; Robert Huddart; Vincent Khoo; Ros Eeles; Matthew R Sydes; Colin S Cooper; David Dearnaley; Chris Parker

doi:10.1016/j.ijrobp.2009.07.1728

Expression of Bcl-2, p53, and MDM2 in localized prostate cancer with respect to the outcome of radical radiotherapy dose escalation

Roy Vergis, Catherine M Corbishley, Karen Thomas, Alan Horwich, Robert Huddart, Vincent Khoo, Ros Eeles, Matthew R Sydes, Colin S Cooper, David Dearnaley, Chris Parker

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Established prognostic factors in localized prostate cancer explain only a moderate proportion of variation in outcome. We analyzed tumor expression of apoptotic markers with respect to outcome in men with localized prostate cancer in two randomized controlled trials of radiotherapy dose escalation.

Original language	English
Pages (from-to)	35-41
Number of pages	7
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	78
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2009.07.1728
Publication status	Published - 1 Sep 2010

Keywords

Aged
Aged, 80 and over
Analysis of Variance
Androgen Antagonists
Follow-Up Studies
Humans
Male
Middle Aged
Neoadjuvant Therapy
Neoplasm Proteins
Neoplasm Staging
Prostate-Specific Antigen
Prostatic Neoplasms
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-mdm2
Radiotherapy Dosage
Tissue Array Analysis
Tumor Suppressor Protein p53

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijrobp.2009.07.1728

Cite this

Vergis, R., Corbishley, C. M., Thomas, K., Horwich, A., Huddart, R., Khoo, V., Eeles, R., Sydes, M. R., Cooper, C. S., Dearnaley, D., & Parker, C. (2010). Expression of Bcl-2, p53, and MDM2 in localized prostate cancer with respect to the outcome of radical radiotherapy dose escalation. International Journal of Radiation Oncology, Biology, Physics, 78(1), 35-41. https://doi.org/10.1016/j.ijrobp.2009.07.1728

Vergis, Roy ; Corbishley, Catherine M ; Thomas, Karen ; Horwich, Alan ; Huddart, Robert ; Khoo, Vincent ; Eeles, Ros ; Sydes, Matthew R ; Cooper, Colin S ; Dearnaley, David ; Parker, Chris. / Expression of Bcl-2, p53, and MDM2 in localized prostate cancer with respect to the outcome of radical radiotherapy dose escalation. In: International Journal of Radiation Oncology, Biology, Physics. 2010 ; Vol. 78, No. 1. pp. 35-41.

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title = "Expression of Bcl-2, p53, and MDM2 in localized prostate cancer with respect to the outcome of radical radiotherapy dose escalation",

abstract = "Established prognostic factors in localized prostate cancer explain only a moderate proportion of variation in outcome. We analyzed tumor expression of apoptotic markers with respect to outcome in men with localized prostate cancer in two randomized controlled trials of radiotherapy dose escalation.",

keywords = "Aged, Aged, 80 and over, Analysis of Variance, Androgen Antagonists, Follow-Up Studies, Humans, Male, Middle Aged, Neoadjuvant Therapy, Neoplasm Proteins, Neoplasm Staging, Prostate-Specific Antigen, Prostatic Neoplasms, Proto-Oncogene Proteins c-bcl-2, Proto-Oncogene Proteins c-mdm2, Radiotherapy Dosage, Tissue Array Analysis, Tumor Suppressor Protein p53",

author = "Roy Vergis and Corbishley, {Catherine M} and Karen Thomas and Alan Horwich and Robert Huddart and Vincent Khoo and Ros Eeles and Sydes, {Matthew R} and Cooper, {Colin S} and David Dearnaley and Chris Parker",

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doi = "10.1016/j.ijrobp.2009.07.1728",

language = "English",

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journal = "International Journal of Radiation Oncology, Biology, Physics",

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Vergis, R, Corbishley, CM, Thomas, K, Horwich, A, Huddart, R, Khoo, V, Eeles, R, Sydes, MR, Cooper, CS, Dearnaley, D & Parker, C 2010, 'Expression of Bcl-2, p53, and MDM2 in localized prostate cancer with respect to the outcome of radical radiotherapy dose escalation', International Journal of Radiation Oncology, Biology, Physics, vol. 78, no. 1, pp. 35-41. https://doi.org/10.1016/j.ijrobp.2009.07.1728

Expression of Bcl-2, p53, and MDM2 in localized prostate cancer with respect to the outcome of radical radiotherapy dose escalation. / Vergis, Roy; Corbishley, Catherine M; Thomas, Karen; Horwich, Alan; Huddart, Robert; Khoo, Vincent; Eeles, Ros; Sydes, Matthew R; Cooper, Colin S; Dearnaley, David; Parker, Chris.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 78, No. 1, 01.09.2010, p. 35-41.

Research output: Contribution to journal › Article › peer-review

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T1 - Expression of Bcl-2, p53, and MDM2 in localized prostate cancer with respect to the outcome of radical radiotherapy dose escalation

AU - Vergis, Roy

AU - Corbishley, Catherine M

AU - Thomas, Karen

AU - Horwich, Alan

AU - Huddart, Robert

AU - Khoo, Vincent

AU - Eeles, Ros

AU - Sydes, Matthew R

AU - Cooper, Colin S

AU - Dearnaley, David

AU - Parker, Chris

PY - 2010/9/1

Y1 - 2010/9/1

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KW - Aged, 80 and over

KW - Analysis of Variance

KW - Androgen Antagonists

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoadjuvant Therapy

KW - Neoplasm Proteins

KW - Neoplasm Staging

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Proto-Oncogene Proteins c-bcl-2

KW - Proto-Oncogene Proteins c-mdm2

KW - Radiotherapy Dosage

KW - Tissue Array Analysis

KW - Tumor Suppressor Protein p53

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DO - 10.1016/j.ijrobp.2009.07.1728

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JO - International Journal of Radiation Oncology, Biology, Physics

JF - International Journal of Radiation Oncology, Biology, Physics

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