Extracellular matrix regulation of stem cell behavior

Maqsood Ahmed; Charles ffrench-Constant

doi:10.1007/s40778-016-0056-2

Extracellular matrix regulation of stem cell behavior

Maqsood Ahmed, Charles ffrench-Constant

Norwich Medical School

Research output: Contribution to journal › Review article › peer-review

136 Citations (Scopus)

2 Downloads (Pure)

Abstract

Stem cells hold great promise in treating many diseases either through promoting endogenous cell repair or through direct cell transplants. In order to maximize their potential, understanding the fundamental signals and mechanisms that regulate their behavior is essential. The extracellular matrix (ECM) is one such component involved in mediating stem cell fate. Recent studies have made significant progress in understanding stem cell-ECM interactions. Technological developments have provided greater clarity in how cells may sense and respond to the ECM, in particular the physical properties of the matrix. This review summarizes recent developments, providing illustrative examples of the different modes with which the ECM controls both embryonic and adult stem cell behavior.

Original language	English
Pages (from-to)	197-206
Number of pages	10
Journal	Current Stem Cell Reports
Volume	2
Issue number	3
Early online date	7 Jul 2016
DOIs	https://doi.org/10.1007/s40778-016-0056-2
Publication status	Published - Sep 2016

Keywords

Extracellular matrix
Microenvironment
Regeneration
Stem cell niche
Stem cells

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Ahmed_ffrenchConstant_2023_SCSRFinal published version, 677 KBLicence: CC BY

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Extracellular matrix regulation of stem cell behavior

Abstract

Keywords

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