Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells

Ru Liu, Maria O'Connell, Kristen Johnson, Kenneth Pritzker, Nigel Mackman, Robert Terkeltaub

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102 Citations (Scopus)


Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.
Original languageEnglish
Pages (from-to)1145-1155
Number of pages11
JournalArthritis & Rheumatism
Issue number5
Publication statusPublished - May 2000


  • Calcium Pyrophosphate
  • Humans
  • Interleukin-8
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinases
  • Monocytes
  • NF-kappa B
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Signal Transduction
  • Transcription Factor AP-1
  • Uric Acid

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