Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells

Ru Liu, Maria O'Connell, Kristen Johnson, Kenneth Pritzker, Nigel Mackman, Robert Terkeltaub

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.
Original languageEnglish
Pages (from-to)1145-1155
Number of pages11
JournalArthritis & Rheumatism
Volume43
Issue number5
DOIs
Publication statusPublished - May 2000

Keywords

  • Calcium Pyrophosphate
  • Humans
  • Interleukin-8
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinases
  • Monocytes
  • NF-kappa B
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Signal Transduction
  • Transcription Factor AP-1
  • Uric Acid

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