Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells

Ru Liu; Maria O'Connell; Kristen Johnson; Kenneth Pritzker; Nigel Mackman; Robert Terkeltaub

doi:10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T

Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells

Ru Liu, Maria O'Connell, Kristen Johnson, Kenneth Pritzker, Nigel Mackman, Robert Terkeltaub

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Research output: Contribution to journal › Article › peer-review

105 Citations (Scopus)

Abstract

Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.

Original language	English
Pages (from-to)	1145-1155
Number of pages	11
Journal	Arthritis & Rheumatism
Volume	43
Issue number	5
DOIs	https://doi.org/10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T
Publication status	Published - May 2000

Keywords

Calcium Pyrophosphate
Humans
Interleukin-8
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases
Monocytes
NF-kappa B
Promoter Regions, Genetic
RNA, Messenger
Signal Transduction
Transcription Factor AP-1
Uric Acid

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10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T

Cite this

Liu, R., O'Connell, M., Johnson, K., Pritzker, K., Mackman, N., & Terkeltaub, R. (2000). Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis & Rheumatism, 43(5), 1145-1155. https://doi.org/10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T

Liu, Ru ; O'Connell, Maria ; Johnson, Kristen et al. / Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. In: Arthritis & Rheumatism. 2000 ; Vol. 43, No. 5. pp. 1145-1155.

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title = "Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells",

abstract = "Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.",

keywords = "Calcium Pyrophosphate, Humans, Interleukin-8, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinases, Monocytes, NF-kappa B, Promoter Regions, Genetic, RNA, Messenger, Signal Transduction, Transcription Factor AP-1, Uric Acid",

author = "Ru Liu and Maria O'Connell and Kristen Johnson and Kenneth Pritzker and Nigel Mackman and Robert Terkeltaub",

year = "2000",

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language = "English",

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Liu, R, O'Connell, M, Johnson, K, Pritzker, K, Mackman, N & Terkeltaub, R 2000, 'Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells', Arthritis & Rheumatism, vol. 43, no. 5, pp. 1145-1155. https://doi.org/10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T

Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. / Liu, Ru; O'Connell, Maria; Johnson, Kristen et al.
In: Arthritis & Rheumatism, Vol. 43, No. 5, 05.2000, p. 1145-1155.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Liu, Ru

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N2 - Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.

AB - Monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystals cause acute gout and pseudogout, respectively. Because acute gout and pseudogout appear to be dependent on interleukin-8 (IL-8)-induced neutrophil ingress, this study was undertaken to define and compare how MSU and CPPD crystals stimulate IL-8 messenger RNA (mRNA) expression in mononuclear phagocytes.

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KW - Mitogen-Activated Protein Kinases

KW - Monocytes

KW - NF-kappa B

KW - Promoter Regions, Genetic

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KW - Uric Acid

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Liu R, O'Connell M, Johnson K, Pritzker K, Mackman N, Terkeltaub R. Extracellular signal-regulated kinase 1/extracellular signal-regulated kinase 2 mitogen-activated protein kinase signaling and activation of activator protein 1 and nuclear factor kappaB transcription factors play central roles in interleukin-8 expression stimulated by monosodium urate monohydrate and calcium pyrophosphate crystals in monocytic cells. Arthritis & Rheumatism. 2000 May;43(5):1145-1155. doi: 10.1002/1529-0131(200005)43:5<1145::AID-ANR25>3.0.CO;2-T