Extracts of feijoa inhibit toll-like receptor 2 signaling and activate autophagy implicating a role in dietary control of IBD

Noha Ahmed Nasef; Sunali Mehta; Penny Powell; Gareth Marlow; Tom Wileman; Lynnette R. Ferguson

doi:10.1371/journal.pone.0130910

Extracts of feijoa inhibit toll-like receptor 2 signaling and activate autophagy implicating a role in dietary control of IBD

Noha Ahmed Nasef, Sunali Mehta, Penny Powell, Gareth Marlow, Tom Wileman, Lynnette R. Ferguson

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

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Abstract

Inflammatory bowel disease (IBD) is a heterogeneous chronic inflammatory disease affecting the gut with limited treatment success for its sufferers. This suggests the need for better understanding of the different subtypes of the disease as well as nutritional interventions to compliment current treatments. In this study we assess the ability of a hydrophilic feijoa fraction (F3) to modulate autophagy a process known to regulate inflammation, via TLR2 using IBD cell lines.

Original language	English
Article number	e0130910
Journal	PLoS One
Volume	10
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0130910
Publication status	Published - 25 Jun 2015

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10.1371/journal.pone.0130910Licence: CC BY

PONE-D-15-09044R1Final published version, 4.14 MBLicence: CC BY

Penny Powell
- P.Powelluea.acuk
- Norwich Medical School - Associate Professor
- Metabolic Health - Member
- Gastroenterology and Gut Biology - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research
Tom Wileman
- T.Wilemanuea.acuk
- Norwich Medical School - Research Leader
- Metabolic Health - Member
- Gastroenterology and Gut Biology - Member
Person: Research Group Member, Academic, Teaching & Research

Cite this

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abstract = "Inflammatory bowel disease (IBD) is a heterogeneous chronic inflammatory disease affecting the gut with limited treatment success for its sufferers. This suggests the need for better understanding of the different subtypes of the disease as well as nutritional interventions to compliment current treatments. In this study we assess the ability of a hydrophilic feijoa fraction (F3) to modulate autophagy a process known to regulate inflammation, via TLR2 using IBD cell lines.",

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AU - Marlow, Gareth

AU - Wileman, Tom

AU - Ferguson, Lynnette R.

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Extracts of feijoa inhibit toll-like receptor 2 signaling and activate autophagy implicating a role in dietary control of IBD

Abstract

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Penny Powell

Tom Wileman

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