Factors associated with non-adherence to oral IBD medication: A systematic review of the literature 1980–2013

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Background: Non-adherence to oral medication for inflammatory bowel disease (IBD) has been estimated to be 3–45%. Factors found to be associated with non-adherence, while frequently reported, are often conflicting.
Methods: Databases Embase, Medline, CINAHL and PsycINFO were used to identify studies between 2008 and 2013. Results were summarised through vote count, with reference to study quality and participant number.
Results: Seventeen records met the inclusion criteria and were analysed alongside another 15 identified by a previous literature review (Jackson et al, 2010). Factors related to adherence were grouped into four themes: demographic, psychosocial, clinical and medication. Only factors attitudes towards and beliefs about treatment, barriers to taking medication, and membership of a patient support group were found to be consistently
associated with adherence.
Conclusions: Many factors reported to be associated with adherence to oral IBD medication are not supported with any consistency. Further research is needed in areas shown to be consistently associated with adherence.
Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalGastrointestinal Nursing
Issue number9
Publication statusPublished - 19 Nov 2015


  • Irritable Bowel Disease
  • systematic review
  • Non-adherence
  • Medication Adherence
  • Factors

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