Abstract
AIMS: To identify recruitment and retention rate in randomised controlled trials (RCTs) recruiting people with hip or knee OA, and to determine factors which affect these.
MATERIALS & METHODS: Pubmed search identified RCTs published between 2013-2021, recruited people with hip or knee OA. Regression analyses determined participant and trial factors which may have affected recruitment or retention rates.
RESULTS: 215 RCTs were included. Mean recruitment rate was 63.2%. Mean follow-up rate was 88.4%. Trials had higher recruitment rates if publicly-funded (Odd Ratio (OR): 1.47; 95% Confidence Intervals (CI: 1.12, 1.92), did not recruited people with medical comorbidities (OR: 0.55; 95% CI: 0.41, 0.73), offered a drug intervention as their experimental intervention (OR: 0.50; 95% CI: 0.29, 0.88), recruited from hospitals (OR: 1.42; 95% CI: 1.07, 1.80) and had shorter follow-up durations (OR: 0.95; 95% CI: 0.91, 0.99). Trials had higher retention rates if their experimental group had lower baseline pain scores (OR: 1.20; 95% CI: 1.02, 1.41), control group had higher pain scores (OR: 0.84; 95% CI: 0.72, 0.99), recruited from fewer sites (OR: 0.98; 95% CI: 0.96, 0.99), with shorter follow-up durations (OR: 0.96; 95% CI: 0.92, 0.99).
CONCLUSION: Factors which impact on recruitment and retention rates in OA RCTs include: funding source, baseline pain levels, comorbidity status, location and number of recruitment sites and follow-up duration. These factors should be considered when conducting future OA RCTs.
MATERIALS & METHODS: Pubmed search identified RCTs published between 2013-2021, recruited people with hip or knee OA. Regression analyses determined participant and trial factors which may have affected recruitment or retention rates.
RESULTS: 215 RCTs were included. Mean recruitment rate was 63.2%. Mean follow-up rate was 88.4%. Trials had higher recruitment rates if publicly-funded (Odd Ratio (OR): 1.47; 95% Confidence Intervals (CI: 1.12, 1.92), did not recruited people with medical comorbidities (OR: 0.55; 95% CI: 0.41, 0.73), offered a drug intervention as their experimental intervention (OR: 0.50; 95% CI: 0.29, 0.88), recruited from hospitals (OR: 1.42; 95% CI: 1.07, 1.80) and had shorter follow-up durations (OR: 0.95; 95% CI: 0.91, 0.99). Trials had higher retention rates if their experimental group had lower baseline pain scores (OR: 1.20; 95% CI: 1.02, 1.41), control group had higher pain scores (OR: 0.84; 95% CI: 0.72, 0.99), recruited from fewer sites (OR: 0.98; 95% CI: 0.96, 0.99), with shorter follow-up durations (OR: 0.96; 95% CI: 0.92, 0.99).
CONCLUSION: Factors which impact on recruitment and retention rates in OA RCTs include: funding source, baseline pain levels, comorbidity status, location and number of recruitment sites and follow-up duration. These factors should be considered when conducting future OA RCTs.
Original language | English |
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Pages (from-to) | 5-19 |
Number of pages | 15 |
Journal | Physiotherapy Review |
Volume | 27 |
Issue number | 2 |
DOIs | |
Publication status | Published - 30 Jun 2022 |
Keywords
- RCT
- DEsign efficiency
- Recruit
- Follow-up
- Arthritis
- Attrition