Fatal acute haemopericardium associated with rivaroxaban in a patient with non-valvular atrial fibrillation

Siddiq Omer, Frederick Magezi, Martyn Patel, Ali Alsawaf

Research output: Contribution to journalArticlepeer-review


An 82-year-old female was admitted with chest pain and non-specific T wave changes on her ECG. After 72 hours of conservative management she deteriorated with non-specific symptoms including nausea and a single episode of vomiting. Abdominal and Chest X-rays were unremarkable, blood tests showed worsening Acute Kidney Injury (AKI) on Chronic Kidney Disease (CKD); and raised C-Reactive Protein (CRP) with no obvious symptoms or focus of infection. She rapidly deteriorated going into asystole cardiac arrest and attempts at resuscitation failed.

Post-mortem examination suggested the most likely cause of death was acute spontaneous Haemopericardium due to Rivaroxaban therapy which she was on for non-valvular Atrial Fibrillation (AF).

We believe that this might be the first reported mortality with Rivaroxaban-associated spontaneous haemopericardium in the UK.
Original languageEnglish
Pages (from-to)764–766
Number of pages3
JournalAge and Ageing
Issue number5
Early online date17 Jun 2019
Publication statusPublished - Sep 2019

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