Fe Transport and Storage Related to Humans and Pathogens and Oxygen

E. C. Theil; N. E. Le Brun

doi:10.1016/B978-0-08-097774-4.00302-8

Fe Transport and Storage Related to Humans and Pathogens and Oxygen

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Cellular iron transport into and between cells and the concentration inside cells in iron minerals within the giant, ion-channel, cage proteins, ferritins, are central to life. Ferritins are remarkably symmetric, soluble arrays of ion channels and oxidoreductases that initiate Fe³⁺O mineralization as iron concentrates and antioxidants. Direct Fe²⁺/riboregulator interactions control ferritin protein synthesis in animals, through an Fe²⁺ metabolic feedback loop amplified by regulated iron mineral dissolution and protein degradation. Host-protective siphoning of Fe²⁺ from pathogens to intracellular ferritins and pathogen use of H₂O₂ consuming-mini-ferritins to resist host oxidants illustrate inorganic artillery in disease.

Original language	English
Title of host publication	Bioinorganic Fundamentals and Applications
Subtitle of host publication	Metals in Natural Living Systems and Metals in Toxicology and Medicine
Publisher	Elsevier
Pages	21-33
Number of pages	13
Volume	3
ISBN (Print)	9780080965291
DOIs	https://doi.org/10.1016/B978-0-08-097774-4.00302-8
Publication status	Published - Aug 2013

Keywords

Antoxidant
Biominerals
Ferritin
Iron
Iron channels
Noncoding riboregulator (IRE) - RNA
Oxidoreductase
Protein nanocages

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10.1016/B978-0-08-097774-4.00302-8

Cite this

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title = "Fe Transport and Storage Related to Humans and Pathogens and Oxygen",

abstract = "Cellular iron transport into and between cells and the concentration inside cells in iron minerals within the giant, ion-channel, cage proteins, ferritins, are central to life. Ferritins are remarkably symmetric, soluble arrays of ion channels and oxidoreductases that initiate Fe3+O mineralization as iron concentrates and antioxidants. Direct Fe2+/riboregulator interactions control ferritin protein synthesis in animals, through an Fe2+ metabolic feedback loop amplified by regulated iron mineral dissolution and protein degradation. Host-protective siphoning of Fe2+ from pathogens to intracellular ferritins and pathogen use of H2O2 consuming-mini-ferritins to resist host oxidants illustrate inorganic artillery in disease.",

keywords = "Antoxidant, Biominerals, Ferritin, Iron, Iron channels, Noncoding riboregulator (IRE) - RNA, Oxidoreductase, Protein nanocages",

author = "Theil, {E. C.} and {Le Brun}, {N. E.}",

year = "2013",

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language = "English",

isbn = "9780080965291",

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T1 - Fe Transport and Storage Related to Humans and Pathogens and Oxygen

AU - Theil, E. C.

AU - Le Brun, N. E.

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N2 - Cellular iron transport into and between cells and the concentration inside cells in iron minerals within the giant, ion-channel, cage proteins, ferritins, are central to life. Ferritins are remarkably symmetric, soluble arrays of ion channels and oxidoreductases that initiate Fe3+O mineralization as iron concentrates and antioxidants. Direct Fe2+/riboregulator interactions control ferritin protein synthesis in animals, through an Fe2+ metabolic feedback loop amplified by regulated iron mineral dissolution and protein degradation. Host-protective siphoning of Fe2+ from pathogens to intracellular ferritins and pathogen use of H2O2 consuming-mini-ferritins to resist host oxidants illustrate inorganic artillery in disease.

AB - Cellular iron transport into and between cells and the concentration inside cells in iron minerals within the giant, ion-channel, cage proteins, ferritins, are central to life. Ferritins are remarkably symmetric, soluble arrays of ion channels and oxidoreductases that initiate Fe3+O mineralization as iron concentrates and antioxidants. Direct Fe2+/riboregulator interactions control ferritin protein synthesis in animals, through an Fe2+ metabolic feedback loop amplified by regulated iron mineral dissolution and protein degradation. Host-protective siphoning of Fe2+ from pathogens to intracellular ferritins and pathogen use of H2O2 consuming-mini-ferritins to resist host oxidants illustrate inorganic artillery in disease.

KW - Antoxidant

KW - Biominerals

KW - Ferritin

KW - Iron

KW - Iron channels

KW - Noncoding riboregulator (IRE) - RNA

KW - Oxidoreductase

KW - Protein nanocages

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DO - 10.1016/B978-0-08-097774-4.00302-8

M3 - Chapter

AN - SCOPUS:84902560468

SN - 9780080965291

VL - 3

SP - 21

EP - 33

BT - Bioinorganic Fundamentals and Applications

PB - Elsevier

ER -

Fe Transport and Storage Related to Humans and Pathogens and Oxygen

Abstract

Keywords

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