Feasibility of a bioadhesive drug delivery system targeted to oesophageal tissue

H.K Batchelor; M Tang; P.W Dettmar; F.C Hampson; I.G Jolliffe; D.Q.M Craig

doi:10.1016/j.ejpb.2003.10.007

Feasibility of a bioadhesive drug delivery system targeted to oesophageal tissue

H.K Batchelor, M Tang, P.W Dettmar, F.C Hampson, I.G Jolliffe, D.Q.M Craig

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

This contribution examines the feasibility of utilising an oesophageal-adhesive alginate layer to support model drug particles. Such a bioadhesive system offers the prospect of local drug delivery to the oesophagus, which in turn has applications in the treatment of conditions including gastro-oesophageal reflux disease and oesophageal cancer. Surface-modified (amine, carboxylate and sulfate) as well as neutral fluorescent beads were investigated as model drug particles. A fluorescence assay technique was utilised to quantify the extent and duration of adhesion of a fixed dose of these particles to excised porcine oesophageal tissue. Retention of the particles was investigated both from aqueous systems and within an adhesive alginate solution. After 30 min significantly higher adhesion of neutral beads was recorded from the alginate solution as compared to the aqueous suspension (n=6, P0.05).

Original language	English
Pages (from-to)	295-298
Number of pages	4
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	57
Issue number	2
DOIs	https://doi.org/10.1016/j.ejpb.2003.10.007
Publication status	Published - 24 Jan 2004

Keywords

Drug delivery
Oesophagus
Model drug particle
Bioadhesion
Alginate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejpb.2003.10.007

Cite this

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title = "Feasibility of a bioadhesive drug delivery system targeted to oesophageal tissue",

abstract = "This contribution examines the feasibility of utilising an oesophageal-adhesive alginate layer to support model drug particles. Such a bioadhesive system offers the prospect of local drug delivery to the oesophagus, which in turn has applications in the treatment of conditions including gastro-oesophageal reflux disease and oesophageal cancer. Surface-modified (amine, carboxylate and sulfate) as well as neutral fluorescent beads were investigated as model drug particles. A fluorescence assay technique was utilised to quantify the extent and duration of adhesion of a fixed dose of these particles to excised porcine oesophageal tissue. Retention of the particles was investigated both from aqueous systems and within an adhesive alginate solution. After 30 min significantly higher adhesion of neutral beads was recorded from the alginate solution as compared to the aqueous suspension (n=6, P0.05).",

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T1 - Feasibility of a bioadhesive drug delivery system targeted to oesophageal tissue

AU - Batchelor, H.K

AU - Tang, M

AU - Dettmar, P.W

AU - Hampson, F.C

AU - Jolliffe, I.G

AU - Craig, D.Q.M

PY - 2004/1/24

Y1 - 2004/1/24

N2 - This contribution examines the feasibility of utilising an oesophageal-adhesive alginate layer to support model drug particles. Such a bioadhesive system offers the prospect of local drug delivery to the oesophagus, which in turn has applications in the treatment of conditions including gastro-oesophageal reflux disease and oesophageal cancer. Surface-modified (amine, carboxylate and sulfate) as well as neutral fluorescent beads were investigated as model drug particles. A fluorescence assay technique was utilised to quantify the extent and duration of adhesion of a fixed dose of these particles to excised porcine oesophageal tissue. Retention of the particles was investigated both from aqueous systems and within an adhesive alginate solution. After 30 min significantly higher adhesion of neutral beads was recorded from the alginate solution as compared to the aqueous suspension (n=6, P0.05).

AB - This contribution examines the feasibility of utilising an oesophageal-adhesive alginate layer to support model drug particles. Such a bioadhesive system offers the prospect of local drug delivery to the oesophagus, which in turn has applications in the treatment of conditions including gastro-oesophageal reflux disease and oesophageal cancer. Surface-modified (amine, carboxylate and sulfate) as well as neutral fluorescent beads were investigated as model drug particles. A fluorescence assay technique was utilised to quantify the extent and duration of adhesion of a fixed dose of these particles to excised porcine oesophageal tissue. Retention of the particles was investigated both from aqueous systems and within an adhesive alginate solution. After 30 min significantly higher adhesion of neutral beads was recorded from the alginate solution as compared to the aqueous suspension (n=6, P0.05).

KW - Drug delivery

KW - Oesophagus

KW - Model drug particle

KW - Bioadhesion

KW - Alginate

U2 - 10.1016/j.ejpb.2003.10.007

DO - 10.1016/j.ejpb.2003.10.007

M3 - Article

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SP - 295

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JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

SN - 0939-6411

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ER -