Fecal incontinence in systemic sclerosis is secondary to neuropathy

Nora M Thoua, Mostafa Abdel-Halim, Alastair Forbes, Chris P Denton, Anton V Emmanuel

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48 Citations (Scopus)


Systemic sclerosis (SSc) is a chronic multi-system autoimmune disorder with gastrointestinal tract (GIT) involvement in up to 90% of patients and anorectal involvement occurs in up to 50% of patients. The pathogenesis of gastrointestinal abnormalities may be both myogenic and neurogenic. We aimed to identify which anorectal physiological abnormalities correlate with clinical symptoms and thus understand the pathophysiology of anorectal involvement in SSc.
Original languageEnglish
Pages (from-to)597-603
Number of pages7
JournalThe American Journal of Gastroenterology
Issue number4
Publication statusPublished - Apr 2012


  • Aged
  • Anal Canal
  • Analysis of Variance
  • Case-Control Studies
  • Chi-Square Distribution
  • Fecal Incontinence
  • Female
  • Humans
  • Male
  • Manometry
  • Middle Aged
  • Pressure
  • Rectum
  • Reflex, Abdominal
  • Regional Blood Flow
  • Scleroderma, Systemic
  • Sensory Thresholds
  • Statistics, Nonparametric

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