Fecal incontinence in systemic sclerosis is secondary to neuropathy

Nora M Thoua; Mostafa Abdel-Halim; Alastair Forbes; Chris P Denton; Anton V Emmanuel

doi:10.1038/ajg.2011.399

Fecal incontinence in systemic sclerosis is secondary to neuropathy

Nora M Thoua, Mostafa Abdel-Halim, Alastair Forbes, Chris P Denton, Anton V Emmanuel

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Systemic sclerosis (SSc) is a chronic multi-system autoimmune disorder with gastrointestinal tract (GIT) involvement in up to 90% of patients and anorectal involvement occurs in up to 50% of patients. The pathogenesis of gastrointestinal abnormalities may be both myogenic and neurogenic. We aimed to identify which anorectal physiological abnormalities correlate with clinical symptoms and thus understand the pathophysiology of anorectal involvement in SSc.

Original language	English
Pages (from-to)	597-603
Number of pages	7
Journal	The American Journal of Gastroenterology
Volume	107
Issue number	4
DOIs	https://doi.org/10.1038/ajg.2011.399
Publication status	Published - Apr 2012

Keywords

Aged
Anal Canal
Analysis of Variance
Case-Control Studies
Chi-Square Distribution
Fecal Incontinence
Female
Humans
Male
Manometry
Middle Aged
Pressure
Rectum
Reflex, Abdominal
Regional Blood Flow
Scleroderma, Systemic
Sensory Thresholds
Statistics, Nonparametric

Access to Document

10.1038/ajg.2011.399

Cite this

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title = "Fecal incontinence in systemic sclerosis is secondary to neuropathy",

abstract = "Systemic sclerosis (SSc) is a chronic multi-system autoimmune disorder with gastrointestinal tract (GIT) involvement in up to 90% of patients and anorectal involvement occurs in up to 50% of patients. The pathogenesis of gastrointestinal abnormalities may be both myogenic and neurogenic. We aimed to identify which anorectal physiological abnormalities correlate with clinical symptoms and thus understand the pathophysiology of anorectal involvement in SSc.",

keywords = "Aged, Anal Canal, Analysis of Variance, Case-Control Studies, Chi-Square Distribution, Fecal Incontinence, Female, Humans, Male, Manometry, Middle Aged, Pressure, Rectum, Reflex, Abdominal, Regional Blood Flow, Scleroderma, Systemic, Sensory Thresholds, Statistics, Nonparametric",

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AU - Thoua, Nora M

AU - Abdel-Halim, Mostafa

AU - Forbes, Alastair

AU - Denton, Chris P

AU - Emmanuel, Anton V

PY - 2012/4

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AB - Systemic sclerosis (SSc) is a chronic multi-system autoimmune disorder with gastrointestinal tract (GIT) involvement in up to 90% of patients and anorectal involvement occurs in up to 50% of patients. The pathogenesis of gastrointestinal abnormalities may be both myogenic and neurogenic. We aimed to identify which anorectal physiological abnormalities correlate with clinical symptoms and thus understand the pathophysiology of anorectal involvement in SSc.

KW - Aged

KW - Anal Canal

KW - Analysis of Variance

KW - Case-Control Studies

KW - Chi-Square Distribution

KW - Fecal Incontinence

KW - Female

KW - Humans

KW - Male

KW - Manometry

KW - Middle Aged

KW - Pressure

KW - Rectum

KW - Reflex, Abdominal

KW - Regional Blood Flow

KW - Scleroderma, Systemic

KW - Sensory Thresholds

KW - Statistics, Nonparametric

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DO - 10.1038/ajg.2011.399

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JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

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ER -