Ferracyclic carbonyl complexes as anti-inflammatory agents

Mark Wright, Tyler Wooldridge, Maria O'Connell, Joseph Wright

Research output: Contribution to journalArticle

3 Citations (Scopus)
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Abstract

Reaction of Fe(CO)4Br2 with 2-aminopyridine and 2-aminonapthalene yields ferracyclic iron(II) complexes bearing two CO ligands. Irradiation with visible light releases these two CO molecules. Substitution of halide in parent complexes by thioglucose provides significantly and raises the quantum yield for CO release is raised by around five times. The complexes show anti- inflammatory activity in a TNF assay in the dark.
Original languageEnglish
Pages (from-to)4300-4303
Number of pages4
JournalChemical Communications
Volume56
Issue number31
Early online date11 Mar 2020
DOIs
Publication statusPublished - 21 Apr 2020

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