Ferracyclic carbonyl complexes as anti-inflammatory agents

Mark Wright; Tyler Wooldridge; Maria O'Connell; Joseph Wright

doi:10.1039/D0CC01449D

Ferracyclic carbonyl complexes as anti-inflammatory agents

Mark Wright, Tyler Wooldridge, Maria O'Connell, Joseph Wright

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Abstract

Reaction of Fe(CO)4Br2 with 2-aminopyridine and 2-aminonapthalene yields ferracyclic iron(II) complexes bearing two CO ligands. Irradiation with visible light releases these two CO molecules. Substitution of halide in parent complexes by thioglucose provides significantly and raises the quantum yield for CO release is raised by around five times. The complexes show anti- inflammatory activity in a TNF assay in the dark.

Original language	English
Pages (from-to)	4300-4303
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	31
Early online date	11 Mar 2020
DOIs	https://doi.org/10.1039/D0CC01449D
Publication status	Published - 21 Apr 2020

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10.1039/D0CC01449D

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abstract = "Reaction of Fe(CO)4Br2 with 2-aminopyridine and 2-aminonapthalene yields ferracyclic iron(II) complexes bearing two CO ligands. Irradiation with visible light releases these two CO molecules. Substitution of halide in parent complexes by thioglucose provides significantly and raises the quantum yield for CO release is raised by around five times. The complexes show anti- inflammatory activity in a TNF assay in the dark.",

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AU - Wooldridge, Tyler

AU - O'Connell, Maria

AU - Wright, Joseph

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N2 - Reaction of Fe(CO)4Br2 with 2-aminopyridine and 2-aminonapthalene yields ferracyclic iron(II) complexes bearing two CO ligands. Irradiation with visible light releases these two CO molecules. Substitution of halide in parent complexes by thioglucose provides significantly and raises the quantum yield for CO release is raised by around five times. The complexes show anti- inflammatory activity in a TNF assay in the dark.

AB - Reaction of Fe(CO)4Br2 with 2-aminopyridine and 2-aminonapthalene yields ferracyclic iron(II) complexes bearing two CO ligands. Irradiation with visible light releases these two CO molecules. Substitution of halide in parent complexes by thioglucose provides significantly and raises the quantum yield for CO release is raised by around five times. The complexes show anti- inflammatory activity in a TNF assay in the dark.

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DO - 10.1039/D0CC01449D

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SP - 4300

EP - 4303

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

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ER -

Ferracyclic carbonyl complexes as anti-inflammatory agents

Abstract

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Maria O'Connell

Joseph Wright

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