Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells

Mark Bouwens, Ondine van de Rest, Neele Dellschaft, Mechteld Grootte Bromhaar, Lisette C P G M de Groot, Johanna M Geleijnse, Michael Müller, Lydia A Afman

Research output: Contribution to journalArticlepeer-review

246 Citations (Scopus)

Abstract

Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown.
Original languageEnglish
Pages (from-to)415-424
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume90
Issue number2
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Aged
  • Aged, 80 and over
  • DNA, Complementary
  • Dietary Supplements
  • Docosahexaenoic Acids
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Eicosapentaenoic Acid
  • Fatty Acids, Omega-3
  • Fatty Acids, Unsaturated
  • Female
  • Fish Oils
  • Gene Expression Profiling
  • Humans
  • Inflammation
  • Leukocytes, Mononuclear
  • Male
  • Microarray Analysis
  • Polymerase Chain Reaction
  • RNA

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