Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells

Mark Bouwens; Ondine van de Rest; Neele Dellschaft; Mechteld Grootte Bromhaar; Lisette C P G M de Groot; Johanna M Geleijnse; Michael Müller; Lydia A Afman

doi:10.3945/ajcn.2009.27680

Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells

Mark Bouwens, Ondine van de Rest, Neele Dellschaft, Mechteld Grootte Bromhaar, Lisette C P G M de Groot, Johanna M Geleijnse, Michael Müller, Lydia A Afman

Research output: Contribution to journal › Article › peer-review

266 Citations (Scopus)

Abstract

Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown.

Original language	English
Pages (from-to)	415-424
Number of pages	10
Journal	American Journal of Clinical Nutrition
Volume	90
Issue number	2
DOIs	https://doi.org/10.3945/ajcn.2009.27680
Publication status	Published - Aug 2009

Keywords

Aged
Aged, 80 and over
DNA, Complementary
Dietary Supplements
Docosahexaenoic Acids
Dose-Response Relationship, Drug
Double-Blind Method
Eicosapentaenoic Acid
Fatty Acids, Omega-3
Fatty Acids, Unsaturated
Female
Fish Oils
Gene Expression Profiling
Humans
Inflammation
Leukocytes, Mononuclear
Male
Microarray Analysis
Polymerase Chain Reaction
RNA

Access to Document

10.3945/ajcn.2009.27680

Cite this

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title = "Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells",

abstract = "Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown.",

keywords = "Aged, Aged, 80 and over, DNA, Complementary, Dietary Supplements, Docosahexaenoic Acids, Dose-Response Relationship, Drug, Double-Blind Method, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Fatty Acids, Unsaturated, Female, Fish Oils, Gene Expression Profiling, Humans, Inflammation, Leukocytes, Mononuclear, Male, Microarray Analysis, Polymerase Chain Reaction, RNA",

author = "Mark Bouwens and {van de Rest}, Ondine and Neele Dellschaft and Bromhaar, {Mechteld Grootte} and {de Groot}, {Lisette C P G M} and Geleijnse, {Johanna M} and Michael M{\"u}ller and Afman, {Lydia A}",

year = "2009",

month = aug,

doi = "10.3945/ajcn.2009.27680",

language = "English",

volume = "90",

pages = "415--424",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

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T1 - Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells

AU - Bouwens, Mark

AU - van de Rest, Ondine

AU - Dellschaft, Neele

AU - Bromhaar, Mechteld Grootte

AU - de Groot, Lisette C P G M

AU - Geleijnse, Johanna M

AU - Müller, Michael

AU - Afman, Lydia A

PY - 2009/8

Y1 - 2009/8

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KW - Aged

KW - Aged, 80 and over

KW - DNA, Complementary

KW - Dietary Supplements

KW - Docosahexaenoic Acids

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Eicosapentaenoic Acid

KW - Fatty Acids, Omega-3

KW - Fatty Acids, Unsaturated

KW - Female

KW - Fish Oils

KW - Gene Expression Profiling

KW - Humans

KW - Inflammation

KW - Leukocytes, Mononuclear

KW - Male

KW - Microarray Analysis

KW - Polymerase Chain Reaction

KW - RNA

U2 - 10.3945/ajcn.2009.27680

DO - 10.3945/ajcn.2009.27680

M3 - Article

C2 - 19515734

VL - 90

SP - 415

EP - 424

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 2

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