Flavonoid derivatives as organometallic bioprobes

Christopher E. Anson, Colin S. Creaser, Andrej V. Malkov, Ljubica Mojovic, G. Richard Stephenson

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The synthesis of organoiron derivatives of biologically active flavonoids is described. Lithium enolates of functionalised protected acetophenones and metallated derivatives of substituted aromatic rings have been employed as nucleophiles in combination with tricarbonyl(eta(5)-cyclohexadienyl)iron electrophiles. Products have been converted into flavonoid and chalcone derivatives. Enolates generated from protected flavanones have also been used in nucleophile addition reactions, and a one-pot in situ protection, nucleophile addition, deprotection sequence is reported. (C) 2003 Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)101-122
Number of pages22
JournalJournal of Organometallic Chemistry
Volume668
Issue number1-2
DOIs
Publication statusPublished - 2003
Event1st International Symposium on Bioorganometallic Chemistry - Paris, France
Duration: 18 Jun 200220 Jun 2002

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