Abstract
Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have emerged readily and recent data have shown that resistance to this class of antibiotics can have diverse, species-dependent impacts on host-strain fitness. Here we outline the impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains.
Original language | English |
---|---|
Pages (from-to) | 438-445 |
Number of pages | 8 |
Journal | Trends in Microbiology |
Volume | 22 |
Issue number | 8 |
Early online date | 16 May 2014 |
DOIs | |
Publication status | Published - 1 Aug 2014 |
Keywords
- Chromosome structure
- Fitness
Profiles
-
Mark Webber
- Norwich Medical School - Honorary Professor, Research Leader/Principal Investigator
Person: Honorary, Academic, Teaching & Research