Fluoroquinolone resistance: Mechanisms, impact on bacteria, and role in evolutionary success

Liam S. Redgrave, Sam B. Sutton, Mark A. Webber, Laura J V Piddock

Research output: Contribution to journalReview article

411 Citations (Scopus)

Abstract

Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly used to treat a range of infections. Resistance to these agents is multifactorial and can be via one or a combination of target-site gene mutations, increased production of multidrug-resistance (MDR) efflux pumps, modifying enzymes, and/or target-protection proteins. Fluoroquinolone-resistant clinical isolates of bacteria have emerged readily and recent data have shown that resistance to this class of antibiotics can have diverse, species-dependent impacts on host-strain fitness. Here we outline the impacts of quinolone-resistance mutations in relation to the fitness and evolutionary success of mutant strains.

Original languageEnglish
Pages (from-to)438-445
Number of pages8
JournalTrends in Microbiology
Volume22
Issue number8
Early online date16 May 2014
DOIs
Publication statusPublished - 1 Aug 2014

Keywords

  • Chromosome structure
  • Fitness

Cite this