Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

S Merson, Z H Yang, D Brewer, D Olmos, A Eichholz, F McCarthy, G Fisher, G Kovacs, D M Berney, C S Foster, H Møller, P Scardino, J Cuzick, C S Cooper, Jeremy Clark, Transatlantic Prostate Group

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20 Citations (Scopus)

Abstract

Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone deprivation therapy.
Original languageEnglish
Pages (from-to)1655-1662
Number of pages8
JournalBritish Journal of Cancer
Volume110
Issue number6
DOIs
Publication statusPublished - 18 Mar 2014

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