Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

S Merson; Z H Yang; D Brewer; D Olmos; A Eichholz; F McCarthy; G Fisher; G Kovacs; D M Berney; C S Foster; H Møller; P Scardino; J Cuzick; C S Cooper; Jeremy Clark; Transatlantic Prostate Group

doi:10.1038/bjc.2014.13

Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

S Merson, Z H Yang, D Brewer, D Olmos, A Eichholz, F McCarthy, G Fisher, G Kovacs, D M Berney, C S Foster, H Møller, P Scardino, J Cuzick, C S Cooper, Jeremy Clark, Transatlantic Prostate Group

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone deprivation therapy.

Original language	English
Pages (from-to)	1655-1662
Number of pages	8
Journal	British Journal of Cancer
Volume	110
Issue number	6
DOIs	https://doi.org/10.1038/bjc.2014.13
Publication status	Published - 18 Mar 2014

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10.1038/bjc.2014.13Licence: CC BY-NC-SA

Daniel Brewer
- D.Breweruea.acuk
- Norwich Medical School - Professor in Medical Bioinformatics and Genomics
- Metabolic Health - Member
- Cancer Studies - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching and Research
Colin Cooper
- Colin.Cooperuea.acuk
- Norwich Medical School - Professor of Cancer Genetics
- Metabolic Health - Member
- Cancer Studies - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching and Research

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Merson, S., Yang, Z. H., Brewer, D., Olmos, D., Eichholz, A., McCarthy, F., Fisher, G., Kovacs, G., Berney, D. M., Foster, C. S., Møller, H., Scardino, P., Cuzick, J., Cooper, C. S., Clark, J., & Transatlantic Prostate Group (2014). Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer. British Journal of Cancer, 110(6), 1655-1662. https://doi.org/10.1038/bjc.2014.13

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abstract = "Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone deprivation therapy.",

author = "S Merson and Yang, {Z H} and D Brewer and D Olmos and A Eichholz and F McCarthy and G Fisher and G Kovacs and Berney, {D M} and Foster, {C S} and H M{\o}ller and P Scardino and J Cuzick and Cooper, {C S} and Jeremy Clark and {Transatlantic Prostate Group}",

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Merson, S, Yang, ZH, Brewer, D, Olmos, D, Eichholz, A, McCarthy, F, Fisher, G, Kovacs, G, Berney, DM, Foster, CS, Møller, H, Scardino, P, Cuzick, J, Cooper, CS , Clark, J & Transatlantic Prostate Group 2014, 'Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer', British Journal of Cancer, vol. 110, no. 6, pp. 1655-1662. https://doi.org/10.1038/bjc.2014.13

TY - JOUR

T1 - Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

AU - Merson, S

AU - Yang, Z H

AU - Brewer, D

AU - Olmos, D

AU - Eichholz, A

AU - McCarthy, F

AU - Fisher, G

AU - Kovacs, G

AU - Berney, D M

AU - Foster, C S

AU - Møller, H

AU - Scardino, P

AU - Cuzick, J

AU - Cooper, C S

AU - Clark, Jeremy

AU - Transatlantic Prostate Group

PY - 2014/3/18

Y1 - 2014/3/18

N2 - Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone deprivation therapy.

AB - Androgen receptor (AR)-gene amplification, found in 20-30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone deprivation therapy.

U2 - 10.1038/bjc.2014.13

DO - 10.1038/bjc.2014.13

M3 - Article

C2 - 24481405

SN - 0007-0920

VL - 110

SP - 1655

EP - 1662

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 6

ER -

Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

Abstract

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Daniel Brewer

Colin Cooper

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