TY - JOUR
T1 - Focal retrograde amnesia
T2 - Extending the clinical syndrome of transient epileptic amnesia
AU - Hornberger, Michael
AU - Mohamed, Armin
AU - Miller, Laurie
AU - Watson, John
AU - Thayer, Zoe
AU - Hodges, John R.
PY - 2010/10
Y1 - 2010/10
N2 - A 44-year-old woman presented with focal retrograde amnesia and complaints of rapid forgetting in the absence of episodes of transient cognitive disturbance. Her MRI and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) were normal. On standard neuropsychological tests she performed within the normal range although a test of autobiographical memory confirmed impoverished recall especially involving recent life events. The electroencephalograph (EEG) recordings were suggestive of temporal lobe epilepsy but no clear diagnosis was established. After 4 years the patient's recurrent brief episodes of disorientation, suggestive of transient epileptic amnesia (TEA), were corroborated by her sister. This diagnosis was confirmed by an ambulatory EEG that revealed ictal activity. Several important points emerge from this study. Focal retrograde amnesia can be a prodromal symptom of TEA which can precede the full-blown syndrome by several years. Moreover, transient attacks might not be reported if patients live alone. The ictal EEG findings further substantiate the epileptic nature of the syndrome.
AB - A 44-year-old woman presented with focal retrograde amnesia and complaints of rapid forgetting in the absence of episodes of transient cognitive disturbance. Her MRI and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) were normal. On standard neuropsychological tests she performed within the normal range although a test of autobiographical memory confirmed impoverished recall especially involving recent life events. The electroencephalograph (EEG) recordings were suggestive of temporal lobe epilepsy but no clear diagnosis was established. After 4 years the patient's recurrent brief episodes of disorientation, suggestive of transient epileptic amnesia (TEA), were corroborated by her sister. This diagnosis was confirmed by an ambulatory EEG that revealed ictal activity. Several important points emerge from this study. Focal retrograde amnesia can be a prodromal symptom of TEA which can precede the full-blown syndrome by several years. Moreover, transient attacks might not be reported if patients live alone. The ictal EEG findings further substantiate the epileptic nature of the syndrome.
KW - Autobiographical memory
KW - Ictal epileptic activity
KW - Prodromal TEA
KW - Retrograde amnesia
KW - Transient epileptic amnesia
UR - http://www.scopus.com/inward/record.url?scp=77955660820&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2010.03.005
DO - 10.1016/j.jocn.2010.03.005
M3 - Article
C2 - 20598890
AN - SCOPUS:77955660820
SN - 0967-5868
VL - 17
SP - 1319
EP - 1321
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
IS - 10
ER -