From guidelines to clinical practice: The impact of hospital and geographical characteristics on temporal trends in the management of acute coronary syndromes. The Global Registry of Acute Coronary Events (GRACE)

Keith A. A. Fox, Shaun G. Goodman, Frederick A. Anderson, Christopher B. Granger, Mauro Moscucci, Marcus D. Flather, Frederick Spencer, Andrzej Budaj, Omar H. Dabbous, Joel M. Gore, GRACE Investigators

Research output: Contribution to journalArticlepeer-review

246 Citations (Scopus)


The extent to which hospital and geographic characteristics influence the time course of uptake of evidence from key clinical trials and practice guidelines is unknown. The gap between evidence and practice is well recognized but the factors influencing this disjunction, and the extent to which such factors are modifiable, remain uncertain.
Original languageEnglish
Pages (from-to)1414-1424
Number of pages11
JournalEuropean Heart Journal
Issue number15
Publication statusPublished - Aug 2003


  • Adrenergic beta-Antagonists
  • Aged
  • Angioplasty, Balloon, Coronary
  • Anticoagulants
  • Aspirin
  • Cardiac Catheterization
  • Evidence-Based Medicine
  • Female
  • Heparin, Low-Molecular-Weight
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Practice Guidelines as Topic
  • Syndrome

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