TY - JOUR
T1 - From molecule to clinic and community for neurodegeneration
T2 - research to bridge translational gaps
AU - Brayne, Carol
AU - Barker, Roger A
AU - Harold, Denise
AU - Ince, Paul G
AU - Savva, George M
AU - Williams, Julie
AU - Williams-Gray, Caroline H
AU - Wharton, Stephen B
PY - 2013
Y1 - 2013
N2 - Six papers based on studies with particular epidemiological designs are presented here which have been selected on the basis of their visibility in the literature. The designs are intended to provide robust evidence on risk, natural history, and underpinning neurobiology and outcomes relevant to aging populations. There is a large case control study (the Late Onset Alzheimer's Disease study), a case cohort study of Parkinson's Disease (the CamPaIGN study), and the Medical Research Council Cognitive Function and Ageing Study. Each study has included genetic investigation and risk, and the latter two include investigation of the clinical syndromes and their natural histories in relation to underlying pathology. Each aimed to provide results which were as generalizable to usual older populations as possible and each has produced findings which have contributed to current understanding of genetic risk, the heterogeneity of the syndrome of Parkinson's disease, and the underlying neuropathology of dementia in older population. They have influenced thinking about future directions, and the cohorts on which the findings are based will continue to provide an important resource for novel areas of research and future health care planning.
AB - Six papers based on studies with particular epidemiological designs are presented here which have been selected on the basis of their visibility in the literature. The designs are intended to provide robust evidence on risk, natural history, and underpinning neurobiology and outcomes relevant to aging populations. There is a large case control study (the Late Onset Alzheimer's Disease study), a case cohort study of Parkinson's Disease (the CamPaIGN study), and the Medical Research Council Cognitive Function and Ageing Study. Each study has included genetic investigation and risk, and the latter two include investigation of the clinical syndromes and their natural histories in relation to underlying pathology. Each aimed to provide results which were as generalizable to usual older populations as possible and each has produced findings which have contributed to current understanding of genetic risk, the heterogeneity of the syndrome of Parkinson's disease, and the underlying neuropathology of dementia in older population. They have influenced thinking about future directions, and the cohorts on which the findings are based will continue to provide an important resource for novel areas of research and future health care planning.
KW - Aging
KW - Disease Progression
KW - Humans
KW - Neurodegenerative Diseases
KW - Risk
KW - Translational Medical Research
U2 - 10.3233/JAD-2012-129006
DO - 10.3233/JAD-2012-129006
M3 - Article
C2 - 22647264
SN - 1875-8908
VL - 33
SP - S385-96
JO - Journal of Alzheimers Disease
JF - Journal of Alzheimers Disease
IS - 1
ER -