TY - JOUR
T1 - Functional diversification of a wild potato immune receptor at its center of origin
AU - Ascurra, Yerisf C. Torres
AU - Zhang, Lisha
AU - Toghani, Amirali
AU - Hua, Chenlei
AU - Rangegowda, Nandeesh Jalahalli
AU - Posbeyikian, Andres
AU - Pai, Hsuan
AU - Lin, Xiao
AU - Wolters, Pieter J.
AU - Wouters, Doret
AU - de Blok, Reinhoud
AU - Steigenga, Niels
AU - Paillart, Maxence J. M.
AU - Visser, Richard G. F.
AU - Kamoun, Sophien
AU - Nürnberger, Thorsten
AU - Vleeshouwers, Vivianne G. A. A.
N1 - Data and materials availability: Sequences of cloned homologs were deposited in the National Center for Biotechnology Information database, www.ncbi.nlm.nih.gov (accession nos. OQ999431 to OQ999482). All other data, sequences, datasets, and scripts for the phylogenomic analyses are available in the manuscript, the supplementary material or deposited at Zenodo (46). Most of the wild Solanum accessions were in possession of WUR Plant Breeding before Nagoya rules applied, part of the material was obtained later from the Center of Genetic Resources, The Netherlands for which we refer to Access and Benefit-Sharing (https://www.absfocalpoint.nl/en/absfocalpoint.htm) at their website (https://cgngenis.wur.nl).
Funding: This work was supported by the following: Peruvian Council for science, technology and technological innovation (CONCYTEC) FONDECYT contract 129-2017 (to Y.C.T.A.); Deutsche Forschungsgemeinschaft grant CRC1101-D10 and Nu70/17-1 (to T.N.); The Gatsby Charitable Foundation BBSRC, UK, BBS/E/J/000PR9795; BBSRC, UK, BBS/E/J/000PR9796; BBSRC, UK, BS/E/J/000PR9798.
PY - 2023/8/25
Y1 - 2023/8/25
N2 - Plant cell surface pattern recognition receptors (PRRs) and intracellular immune receptors cooperate to provide immunity to microbial infection. Both receptor families have coevolved at an accelerated rate, but the evolution and diversification of PRRs is poorly understood. We have isolated potato surface receptor Pep-13 receptor unit (PERU) that senses Pep-13, a conserved immunogenic peptide pattern from plant pathogenic Phytophthora species. PERU, a leucine-rich repeat receptor kinase, is a bona fide PRR that binds Pep-13 and enhances immunity to Phytophthora infestans infection. Diversification in ligand binding specificities of PERU can be traced to sympatric wild tuber-bearing Solanum populations in the Central Andes. Our study reveals the evolution of cell surface immune receptor alleles in wild potato populations that recognize ligand variants not recognized by others.
AB - Plant cell surface pattern recognition receptors (PRRs) and intracellular immune receptors cooperate to provide immunity to microbial infection. Both receptor families have coevolved at an accelerated rate, but the evolution and diversification of PRRs is poorly understood. We have isolated potato surface receptor Pep-13 receptor unit (PERU) that senses Pep-13, a conserved immunogenic peptide pattern from plant pathogenic Phytophthora species. PERU, a leucine-rich repeat receptor kinase, is a bona fide PRR that binds Pep-13 and enhances immunity to Phytophthora infestans infection. Diversification in ligand binding specificities of PERU can be traced to sympatric wild tuber-bearing Solanum populations in the Central Andes. Our study reveals the evolution of cell surface immune receptor alleles in wild potato populations that recognize ligand variants not recognized by others.
UR - http://www.scopus.com/inward/record.url?scp=85168742929&partnerID=8YFLogxK
U2 - 10.1126/science.adg5261
DO - 10.1126/science.adg5261
M3 - Article
C2 - 37616352
AN - SCOPUS:85168742929
SN - 0036-8075
VL - 381
SP - 891
EP - 897
JO - Science
JF - Science
IS - 6660
ER -