Functional diversification of a wild potato immune receptor at its center of origin

Yerisf C. Torres Ascurra; Lisha Zhang; Amirali Toghani; Chenlei Hua; Nandeesh Jalahalli Rangegowda; Andres Posbeyikian; Hsuan Pai; Xiao Lin; Pieter J. Wolters; Doret Wouters; Reinhoud de Blok; Niels Steigenga; Maxence J. M. Paillart; Richard G. F. Visser; Sophien Kamoun; Thorsten Nürnberger; Vivianne G. A. A. Vleeshouwers

doi:10.1126/science.adg5261

Functional diversification of a wild potato immune receptor at its center of origin

Yerisf C. Torres Ascurra, Lisha Zhang, Amirali Toghani, Chenlei Hua, Nandeesh Jalahalli Rangegowda, Andres Posbeyikian, Hsuan Pai, Xiao Lin, Pieter J. Wolters, Doret Wouters, Reinhoud de Blok, Niels Steigenga, Maxence J. M. Paillart, Richard G. F. Visser, Sophien Kamoun, Thorsten Nürnberger, Vivianne G. A. A. Vleeshouwers

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Plant cell surface pattern recognition receptors (PRRs) and intracellular immune receptors cooperate to provide immunity to microbial infection. Both receptor families have coevolved at an accelerated rate, but the evolution and diversification of PRRs is poorly understood. We have isolated potato surface receptor Pep-13 receptor unit (PERU) that senses Pep-13, a conserved immunogenic peptide pattern from plant pathogenic Phytophthora species. PERU, a leucine-rich repeat receptor kinase, is a bona fide PRR that binds Pep-13 and enhances immunity to Phytophthora infestans infection. Diversification in ligand binding specificities of PERU can be traced to sympatric wild tuber-bearing Solanum populations in the Central Andes. Our study reveals the evolution of cell surface immune receptor alleles in wild potato populations that recognize ligand variants not recognized by others.

Original language	English
Pages (from-to)	891-897
Number of pages	7
Journal	Science
Volume	381
Issue number	6660
Early online date	24 Aug 2023
DOIs	https://doi.org/10.1126/science.adg5261
Publication status	Published - 25 Aug 2023

Access to Document

10.1126/science.adg5261

Cite this

Ascurra, Y. C. T., Zhang, L., Toghani, A., Hua, C., Rangegowda, N. J., Posbeyikian, A., Pai, H., Lin, X., Wolters, P. J., Wouters, D., de Blok, R., Steigenga, N., Paillart, M. J. M., Visser, R. G. F., Kamoun, S., Nürnberger, T., & Vleeshouwers, V. G. A. A. (2023). Functional diversification of a wild potato immune receptor at its center of origin. Science, 381(6660), 891-897. https://doi.org/10.1126/science.adg5261

@article{95d736b4e38044a7bdc6fd432326f577,

title = "Functional diversification of a wild potato immune receptor at its center of origin",

abstract = "Plant cell surface pattern recognition receptors (PRRs) and intracellular immune receptors cooperate to provide immunity to microbial infection. Both receptor families have coevolved at an accelerated rate, but the evolution and diversification of PRRs is poorly understood. We have isolated potato surface receptor Pep-13 receptor unit (PERU) that senses Pep-13, a conserved immunogenic peptide pattern from plant pathogenic Phytophthora species. PERU, a leucine-rich repeat receptor kinase, is a bona fide PRR that binds Pep-13 and enhances immunity to Phytophthora infestans infection. Diversification in ligand binding specificities of PERU can be traced to sympatric wild tuber-bearing Solanum populations in the Central Andes. Our study reveals the evolution of cell surface immune receptor alleles in wild potato populations that recognize ligand variants not recognized by others.",

author = "Ascurra, {Yerisf C. Torres} and Lisha Zhang and Amirali Toghani and Chenlei Hua and Rangegowda, {Nandeesh Jalahalli} and Andres Posbeyikian and Hsuan Pai and Xiao Lin and Wolters, {Pieter J.} and Doret Wouters and {de Blok}, Reinhoud and Niels Steigenga and Paillart, {Maxence J. M.} and Visser, {Richard G. F.} and Sophien Kamoun and Thorsten N{\"u}rnberger and Vleeshouwers, {Vivianne G. A. A.}",

year = "2023",

month = aug,

day = "25",

doi = "10.1126/science.adg5261",

language = "English",

volume = "381",

pages = "891--897",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6660",

}

Ascurra, YCT, Zhang, L, Toghani, A, Hua, C, Rangegowda, NJ, Posbeyikian, A, Pai, H, Lin, X, Wolters, PJ, Wouters, D, de Blok, R, Steigenga, N, Paillart, MJM, Visser, RGF, Kamoun, S, Nürnberger, T & Vleeshouwers, VGAA 2023, 'Functional diversification of a wild potato immune receptor at its center of origin', Science, vol. 381, no. 6660, pp. 891-897. https://doi.org/10.1126/science.adg5261

TY - JOUR

T1 - Functional diversification of a wild potato immune receptor at its center of origin

AU - Ascurra, Yerisf C. Torres

AU - Zhang, Lisha

AU - Toghani, Amirali

AU - Hua, Chenlei

AU - Rangegowda, Nandeesh Jalahalli

AU - Posbeyikian, Andres

AU - Pai, Hsuan

AU - Lin, Xiao

AU - Wolters, Pieter J.

AU - Wouters, Doret

AU - de Blok, Reinhoud

AU - Steigenga, Niels

AU - Paillart, Maxence J. M.

AU - Visser, Richard G. F.

AU - Kamoun, Sophien

AU - Nürnberger, Thorsten

AU - Vleeshouwers, Vivianne G. A. A.

PY - 2023/8/25

Y1 - 2023/8/25

N2 - Plant cell surface pattern recognition receptors (PRRs) and intracellular immune receptors cooperate to provide immunity to microbial infection. Both receptor families have coevolved at an accelerated rate, but the evolution and diversification of PRRs is poorly understood. We have isolated potato surface receptor Pep-13 receptor unit (PERU) that senses Pep-13, a conserved immunogenic peptide pattern from plant pathogenic Phytophthora species. PERU, a leucine-rich repeat receptor kinase, is a bona fide PRR that binds Pep-13 and enhances immunity to Phytophthora infestans infection. Diversification in ligand binding specificities of PERU can be traced to sympatric wild tuber-bearing Solanum populations in the Central Andes. Our study reveals the evolution of cell surface immune receptor alleles in wild potato populations that recognize ligand variants not recognized by others.

AB - Plant cell surface pattern recognition receptors (PRRs) and intracellular immune receptors cooperate to provide immunity to microbial infection. Both receptor families have coevolved at an accelerated rate, but the evolution and diversification of PRRs is poorly understood. We have isolated potato surface receptor Pep-13 receptor unit (PERU) that senses Pep-13, a conserved immunogenic peptide pattern from plant pathogenic Phytophthora species. PERU, a leucine-rich repeat receptor kinase, is a bona fide PRR that binds Pep-13 and enhances immunity to Phytophthora infestans infection. Diversification in ligand binding specificities of PERU can be traced to sympatric wild tuber-bearing Solanum populations in the Central Andes. Our study reveals the evolution of cell surface immune receptor alleles in wild potato populations that recognize ligand variants not recognized by others.

UR - http://www.scopus.com/inward/record.url?scp=85168742929&partnerID=8YFLogxK

U2 - 10.1126/science.adg5261

DO - 10.1126/science.adg5261

M3 - Article

C2 - 37616352

AN - SCOPUS:85168742929

VL - 381

SP - 891

EP - 897

JO - Science

JF - Science

SN - 0036-8075

IS - 6660

ER -

Functional diversification of a wild potato immune receptor at its center of origin

Abstract

Access to Document

Other files and links

Cite this